Outcomes after opioid dose reductions and stoppage: It's time to start counting.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of substance abuse treatment"
DOI: 10.1016/j.jsat.2019.05.010
Abstract: ----“We didn’t have a heroin crisis in America before OxyContin was approved and started being handed out like candy...We could fix the majority of this problem with a click of our fingers,” declared Vermont’s Governor,… read more here.
Keywords: outcomes opioid; reductions stoppage; opioid dose; time start ... See more keywords
Safety and impact of dose reductions on efficacy in the randomised MONALEESA-2, -3 and -7 trials in hormone receptor-positive, HER2-negative advanced breast cancer.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of cancer"
DOI: 10.1038/s41416-021-01415-9
Abstract: BACKGROUND This pooled analysis of MONALEESA trials evaluated the safety of ribociclib plus endocrine therapy (RIB + ET) with a focus on dose reductions in first-line patients. METHODS In the dose reduction analysis, data were pooled from… read more here.
Keywords: analysis; safety; dose reductions; monaleesa trials ... See more keywords
Bone metastases and age are associated with earlier dose reductions in metastatic clear-cell renal cell carcinoma patients treated with angiogenesis inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Acta Clinica Belgica"
DOI: 10.1080/17843286.2018.1551744
Abstract: ABSTRACT Background: Metastatic clear-cell renal cell carcinoma (m-ccRCC) patients with bone metastases (BM) treated with vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKI) have a poorer outcome compared to patients without BM. We… read more here.
Keywords: patients treated; age; dose reductions; metastatic clear ... See more keywords
Dofetilide Dose Reductions and Discontinuation in Obese Compared with Nonobese Patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000001353
Abstract: Abstract: Dofetilide is an antiarrhythmic agent and primarily eliminated renally. Initial dosing is determined by creatinine clearance, calculated by total body weight in the Cockcroft–Gault equation. To date, there is no evidence comparing the dosing… read more here.
Keywords: adjustments compared; body weight; nonobese patients; dose reductions ... See more keywords
Abstract PO2-18-01: Assessment of Initial Dosing and Dose Management of Sacituzumab Govitecan-hziy (SG) and How Dosing Practices Impact Duration of Therapy (DOT)
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs23-po2-18-01
Abstract: Background: As the Phase 3 ASCENT trial’s safety analysis found that a 10m/kg dose of SG resulted in better efficacy than treatment with a lower dose, this examination sought to use real-world data to evaluate… read more here.
Keywords: cancer; starting dose; dot pts; dose reductions ... See more keywords
Hospital utilization rates following antipsychotic dose reductions: implications for tardive dyskinesia
Sign Up to like & getrecommendations! Published in 2018 at "BMC Psychiatry"
DOI: 10.1186/s12888-018-1889-2
Abstract: BackgroundData are limited on the benefits and risks of dose reduction in managing side effects associated with antipsychotic treatment. As an example, antipsychotic dose reduction has been recommended in the management of tardive dyskinesia (TD),… read more here.
Keywords: risk; dose reductions; antipsychotic dose; tardive dyskinesia ... See more keywords
A retrospective, single-center study comparing two neoadjuvant protocols for patients with HER2-positive breast cancer.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2024.42.16_suppl.e12623
Abstract: e12623 Background: Neoadjuvant treatment is common in Stage 2+3 HER2 positive tumors. Cytotoxic and anti-HER2 drug combinations are used. Pathological complete response (pCR) correlates with improved survival and decreased risk of relapse. Trastuzumab may cause… read more here.
Keywords: group; her2 positive; dose reductions; retrospective single ... See more keywords
Steering Away from Current Amoxicillin Dose Reductions in Hospitalized Patients with Impaired Kidney Function to Avoid Subtherapeutic Drug Exposure
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11091190
Abstract: Current dose reductions recommended for amoxicillin in patients with impaired kidney function could lead to suboptimal treatments. In a prospective, observational study in hospitalized adults with varying kidney function treated with an IV or oral… read more here.
Keywords: kidney function; kidney; amoxicillin; dose reductions ... See more keywords