Clinical Implications of Complex Pharmacokinetics for Daratumumab Dose Regimen in Patients With Relapsed/Refractory Multiple Myeloma
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DOI: 10.1002/cpt.577
Abstract: New therapeutic strategies are urgently needed to improve clinical outcomes in patients with multiple myeloma (MM). Daratumumab is a first‐in‐class, CD38 human immunoglobulin G1κ monoclonal antibody approved for treatment of relapsed or refractory MM. Identification… read more here.
Keywords: relapsed refractory; clinical implications; multiple myeloma; dose regimen ... See more keywords
0591 Effectiveness and Optimization of Lower-Sodium Oxybate in Participants With Narcolepsy Switching From Sodium Oxybate (SEGUE)
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DOI: 10.1093/sleep/zsad077.0591
Abstract: Lower-sodium oxybate (LXB, Xywav®) contains 92% less sodium than higher-sodium oxybate (SXB, Xyrem®) and is approved for treating cataplexy or excessive daytime sleepiness in patients with narcolepsy (≥7 years of age) and idiopathic hypersomnia in… read more here.
Keywords: participants narcolepsy; sodium; sodium oxybate; dose regimen ... See more keywords
Optimization of initial dose regimen of tacrolimus in paediatric lung transplant recipients based on Monte Carlo simulation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pharmacy and Therapeutics"
DOI: 10.1111/jcpt.13717
Abstract: The initial tacrolimus dose regimen in paediatric lung transplant recipients is unknown. The present study optimized the initial tacrolimus dose regimen for paediatric lung transplant recipients. read more here.
Keywords: paediatric lung; lung transplant; dose regimen; transplant recipients ... See more keywords
SAT0258 Weekly split dose compared with single dose oral methotrexate reduced polyglutamylation in red blood cells and increased the risk of adverse events in patients with rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.5046
Abstract: Background Methotrexate (MTX) is a well-known anchor drug for rheumatoid arthritis (RA); however, dose regimens vary. We previously reported in EULAR2015 that split dose weekly oral methotrexate induced elevation of AST and ALT in association… read more here.
Keywords: none declared; mtx; adverse events; dose regimen ... See more keywords
Comparative efficacy and safety of alternative glucocorticoids regimens in patients with ANCA-associated vasculitis: a systematic review
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DOI: 10.1136/bmjopen-2021-050507
Abstract: Objective To compare the efficacy and safety of alternative glucocorticoids (GCs) regimens as induction therapy for patients with antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis. Design Systematic review of randomised controlled trials (RCTs). Data sources Medline, Embase,… read more here.
Keywords: review; anca associated; dose regimen; efficacy safety ... See more keywords
Efficacy of a single dose versus a multiple dose regimen of Mebendazole against hookworm infections among school children: a randomized open-label trial
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DOI: 10.1186/s12879-020-05097-1
Abstract: Background Despite the existence of a population-based control program using single dose albendazole or mebendazole as a preventive chemotherapy, hookworm transmission remains high. It causes a negative impact on the growth and school performance of… read more here.
Keywords: hookworm infections; multiple dose; school; dose regimen ... See more keywords
Retrospective analysis of relationships among the dose regimen, trough concentration, efficacy, and safety of teicoplanin in Chinese patients with moderate–severe Gram-positive infections [Corrigendum]
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DOI: 10.2147/idr.s204540
Abstract: [This corrects the article on p. 29 in vol. 11, PMID: 29379306.]. read more here.
Keywords: regimen trough; among dose; relationships among; dose regimen ... See more keywords
Pharmacokinetics and Pharmacodynamics of Colistin Methanesulfonate in Healthy Chinese Subjects after Multi-Dose Regimen
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DOI: 10.3390/antibiotics11060798
Abstract: Colistin methanesulfonate (CMS) is an important treatment option for infections caused by carbapenem-resistant Gram-negative organisms (CROs). This study evaluated the pharmacokinetic/pharmacodynamic (PK/PD) profiles and safety of CMS in Chinese subjects following a recommended dosage. A… read more here.
Keywords: chinese subjects; carbapenem resistant; colistin methanesulfonate; dose regimen ... See more keywords
A Mixture of Endocrine Disruptors and the Pesticide Roundup® Induce Oxidative Stress in Rabbit Liver When Administered under the Long-Term Low-Dose Regimen: Reinforcing the Notion of Real-Life Risk Simulation
Sign Up to like & getrecommendations! Published in 2022 at "Toxics"
DOI: 10.3390/toxics10040190
Abstract: Humans are exposed to xenobiotic mixtures daily through the long-term, low-dose regimen. Investigations designed to simulate this exposure profile approach the real-life risk simulation (RLRS) idea of modern toxicology. The purpose of the present study… read more here.
Keywords: long term; roundup; term low; dose regimen ... See more keywords