Design of a Phase III immunogenicity and safety study evaluating two-dose regimens of 9-valent human papillomavirus (9vHPV) vaccine with extended dosing intervals.
Sign Up to like & getrecommendations! Published in 2021 at "Contemporary clinical trials"
DOI: 10.1016/j.cct.2021.106403
Abstract: HPV vaccines are widely licensed as two-dose regimens, 6-12 months apart, for adolescents. Extended intervals between doses may be necessary due to resource constraints or vaccination program disruption. This international, multicenter, open-label study (NCT04708041) will evaluate… read more here.
Keywords: two dose; study; dose regimens; 9vhpv vaccine ... See more keywords
Evaluation of omadacycline regimens for community-acquired bacterial pneumonia patients infected with Staphylococcus Aureus by pharmacokinetic/pharmacodynamic analysis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Chemotherapy"
DOI: 10.1080/1120009x.2024.2343963
Abstract: Abstract Omadacycline is an FDA-approved agent for community-acquired bacterial pneumonia (CABP). The purpose of this study is to evaluate the effectiveness of omadacycline for treating CABP patients infected with Staphylococcus aureus, including Methicillin-Resistant Staphylococcus aureus… read more here.
Keywords: dose regimens; aureus; community acquired; patients infected ... See more keywords
P133 In vitro pharmacological profile of GLPG3667 suggests differentiation from the TYK2 inhibitors deucravacitinib and TAK-279 at their clinical dose regimens
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjad212.0263
Abstract: Tyrosine kinase 2 (TYK2), a Janus kinase (JAK) family member, is attracting a lot of interest as a new target to treat patients with autoimmune and inflammatory diseases, including inflammatory bowel disease, and several inhibitors… read more here.
Keywords: dose regimens; inhibition; tyk2 inhibitors; clinical dose ... See more keywords
Population pharmacokinetic/pharmacodynamic modeling to optimize aztreonam-avibactam dose regimens for adult patients
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DOI: 10.1128/aac.01950-24
Abstract: ABSTRACT Aztreonam-avibactam, a fixed-ratio (3:1) β-lactam/β-lactamase inhibitor combination, was approved in Europe in 2024 for adults with complicated intra-abdominal infection (cIAI), complicated urinary tract infection, hospital-acquired/ventilator-associated pneumonia, and other infections due to aerobic gram-negative organisms… read more here.
Keywords: aztreonam avibactam; population pharmacokinetic; avibactam; dose regimens ... See more keywords
The Fourth Dose of mRNA COVID-19 Vaccine Following 12 Different Three-Dose Regimens: Safety and Immunogenicity to Omicron BA.4/BA.5
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DOI: 10.3390/vaccines11030570
Abstract: Objective: To investigate the reactogenicity and immunogenicity of the fourth dose using mRNA vaccines after different three-dose regimens and to compare the 30 g BNT162b2 and 50 g mRNA-1273 vaccines. Methods: This prospective cohort study… read more here.
Keywords: mrna 1273; fourth dose; dose; three dose ... See more keywords