Lipid levels and the risk of dementia: A dose–response meta‐analysis of prospective cohort studies
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51516
Abstract: We performed a dose–response meta‐analysis to estimate the association between lipid profiles with the risk of dementia and the potential differences according to the subtype of dementia based on prospective studies. read more here.
Keywords: dose response; response meta; meta analysis; risk dementia ... See more keywords
Using dose–response functions to improve calculations of the impact of anthropogenic noise
Sign Up to like & getrecommendations! Published in 2019 at "Aquatic Conservation: Marine and Freshwater Ecosystems"
DOI: 10.1002/aqc.3149
Abstract: Estimating the number of animals impacted by a stressor typically involves combining a dose–response function with information about the distribution of animals and of the stressor. Regulators often prefer a single threshold to a full… read more here.
Keywords: dose response; response; number; stressor ... See more keywords
Glucocorticoid treatment earlier in childhood and adolescence show dose‐response associations with diurnal cortisol levels
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Psychobiology"
DOI: 10.1002/dev.21559
Abstract: Heightened levels of glucocorticoids in children and adolescents have previously been linked to prolonged changes in the diurnal regulation of the stress-hormone cortisol, a glucocorticoid regulated by the hypothalamic-pituitary-adrenal-axis (HPA-axis). To address this question, we… read more here.
Keywords: dose response; cortisol; cortisol levels; diurnal cortisol ... See more keywords
Comparing BMD‐derived genotoxic potency estimations across variants of the transgenic rodent gene mutation assay
Sign Up to like & getrecommendations! Published in 2017 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22137
Abstract: There is growing interest in quantitative analysis of in vivo genetic toxicity dose‐response data, and use of point‐of‐departure (PoD) metrics such as the benchmark dose (BMD) for human health risk assessment (HHRA). Currently, multiple transgenic… read more here.
Keywords: dose response; potency; bmd; transgenic rodent ... See more keywords
Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose–response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose–response data
Sign Up to like & getrecommendations! Published in 2022 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22517
Abstract: Quantitative relationships between carcinogenic potency and mutagenic potency have been previously examined using a benchmark dose (BMD)‐based approach. We extended those analyses by using human exposure data for 48 compounds to calculate carcinogenicity‐derived and genotoxicity‐derived… read more here.
Keywords: carcinogenicity; response data; dose response; genotoxicity ... See more keywords
Quantitative interpretation of ToxTracker dose–response data for potency comparisons and mode‐of‐action determination
Sign Up to like & getrecommendations! Published in 2023 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22525
Abstract: ToxTracker is an in vitro mammalian stem cell‐based reporter assay that detects activation of specific cellular signaling pathways (DNA damage, oxidative stress, and/or protein damage) upon chemical exposure using flow cytometry. Here we used quantitative… read more here.
Keywords: stress; potency; response data; dose response ... See more keywords
Comparison of Power of Trend Tests for Toxicological Application Based on Dose–Response Profiles Enumerated Using a Nonparametric Algorithm
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology and Chemistry"
DOI: 10.1002/etc.5306
Abstract: Tests for dose–response trend may be used to support conclusions on the toxicity of a substance in a range of doses evaluated in a comparative experiment. Criteria are proposed for evaluating and comparing alternative tests,… read more here.
Keywords: power; comparison; dose response; trend tests ... See more keywords
Dose-response assessment of chemically modified curcumin in experimental periodontitis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of periodontology"
DOI: 10.1002/jper.18-0392
Abstract: BACKGROUND CMC2.24, a novel tri-ketonic chemically modified compound based on natural di-ketonic curcumin, has been shown to reduce bone loss and inflammatory mediators in experimental periodontitis, however, a potential dose-response relationship was not determined. The… read more here.
Keywords: production; experimental periodontitis; dose response; chemically modified ... See more keywords
Variations in polyamine conjugates in maize (Zea mays L.) seeds contaminated with aflatoxin B1: A Dose-response relationship.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.10317
Abstract: BACKGROUND Cereal seeds, such as maize seeds, are frequently contaminated with Aflatoxin B1 (AFB1), one of the most dangerous naturally occurring carcinogens. In plants, phenolamides are involved in biotic stress response. The data on variations… read more here.
Keywords: dose response; seed; response; contaminated aflatoxin ... See more keywords
The dose response of high-resolution diode-type detectors and the role of their structural components in strong magnetic field.
Sign Up to like & getrecommendations! Published in 2020 at "Medical physics"
DOI: 10.1002/mp.14535
Abstract: PURPOSE This study aims to investigate the dose response of diode-type detectors in the presence of strong magnetic field and to understand the underlying mechanisms leading to the observed magnetic field dependence by close examinations… read more here.
Keywords: dose response; magnetic field; field; diode type ... See more keywords
Dose–response association between long‐term weight loss in young adults and later‐life metabolic health
Sign Up to like & getrecommendations! Published in 2022 at "Obesity"
DOI: 10.1002/oby.23436
Abstract: Long‐term weight loss (LTWL) has been shown to be associated with lower metabolic risk in young adults with overweight/obesity. However, the dose–response association is uncertain. read more here.
Keywords: long term; term weight; response association; dose response ... See more keywords