Effect of efavirenz-based antiretroviral therapy and high-dose rifampicin on the pharmacokinetics of isoniazid and acetyl-isoniazid
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DOI: 10.1093/jac/dky378
Abstract: Objectives To describe the pharmacokinetics of isoniazid and acetyl-isoniazid in TB/HIV-coinfected patients, and assess the effects of efavirenz co-administration and a 50% increase in the dose of rifampicin on the pharmacokinetic parameters of isoniazid and… read more here.
Keywords: dose rifampicin; isoniazid; isoniazid acetyl; pharmacokinetics isoniazid ... See more keywords
Individualised dosing algorithm and personalised treatment of high‐dose rifampicin for tuberculosis
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DOI: 10.1111/bcp.14048
Abstract: To propose new exposure targets for Bayesian dose optimisation suited for high‐dose rifampicin and to apply them using measured plasma concentrations coupled with a Bayesian forecasting algorithm allowing predictions of future doses, considering rifampicin's auto‐induction,… read more here.
Keywords: high dose; dose rifampicin; algorithm; individualised dosing ... See more keywords
Population-wide administration of single dose rifampicin for leprosy prevention in isolated communities: a three year follow-up feasibility study in Indonesia
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DOI: 10.1186/s12879-018-3233-3
Abstract: BackgroundIndonesia ranking third in the world, regarding leprosy burden. Chemoprophylaxis is effective in reducing risk of developing leprosy among contacts. ‘Blanket approach’ is an operational strategy for leprosy post-exposure prophylaxis in which all members of… read more here.
Keywords: dose rifampicin; prevention isolated; population wide; leprosy prevention ... See more keywords