Efficacy and safety of high-dose tigecycline for the treatment of infectious diseases
Sign Up to like & getrecommendations! Published in 2019 at "Medicine"
DOI: 10.1097/md.0000000000017091
Abstract: Abstract Background: High-dose (HD) tigecycline regimen is increasingly used in infectious diseases, however its efficacy and safety versus low-dose (LD) is still unclear. Methods: A systematic review and meta-analysis was performed; PubMed, Embase, Cochrane Library,… read more here.
Keywords: efficacy safety; high dose; infectious diseases; tigecycline ... See more keywords
Pharmacokinetic/pharmacodynamic analysis of high‐dose tigecycline, by Monte Carlo simulation, in plasma and sputum of patients with hospital‐acquired pneumonia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pharmacy and Therapeutics"
DOI: 10.1111/jcpt.13823
Abstract: To Investigate the pharmacokinetic/pharmacodynamic (PK/PD) parameters of high‐dose tigecycline in plasma and sputum of patients with hospital‐acquired pneumonia (HAP), and provide a therapeutic regimen of multidrug‐resistant bacteria (MDRB) infections. read more here.
Keywords: plasma sputum; sputum patients; pharmacokinetic pharmacodynamic; patients hospital ... See more keywords
Intravenous Polymyxin B as Adjunctive Therapy to High-Dose Tigecycline for the Treatment of Nosocomial Pneumonia Due to Carbapenem-Resistant Acinetobacter baumannii and Klebsiella pneumoniae: A Propensity Score-Matched Cohort Study
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DOI: 10.3390/antibiotics12020273
Abstract: Although the combination of polymyxin and tigecycline is widely used in treating carbapenem-resistant bacterial infections, the benefit of this combination is still uncertain. To assess whether adding polymyxin B to the high-dose tigecycline regimen would… read more here.
Keywords: carbapenem resistant; matched cohort; dose tigecycline; high dose ... See more keywords