Evaluation of Methylphenidate Safety and Maximum-Dose Titration Rationale in Attention-Deficit/Hyperactivity Disorder: A Meta-analysis.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA pediatrics"
DOI: 10.1001/jamapediatrics.2019.0905
Abstract: Importance Evidence on the titration of stimulant medications for attention-deficit/hyperactivity disorder (ADHD) is lacking. However, this lack of evidence has not prevented medication guidelines from specifying apparently arbitrary dose limitations, which could discourage clinicians from… read more here.
Keywords: titration; dose titration; disorder; maximum dose ... See more keywords
THU0608 Association between allopurinol dose-titration and serum uric acid levels in gout patients: us electronic health record data
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-eular.6314
Abstract: Background Allopurinol is a first-line urate lowering therapy for patients with gout. The American College of Rheumatology guidelines recommend allopurinol dose-titration to maintain serum uric acid (sUA) levels TD), or no-dose-change (ID = TD). For… read more here.
Keywords: allopurinol dose; titration; employee; dose titration ... See more keywords
Dose Titration Algorithm Tuning (DTAT) should supersede the Maximum Tolerated Dose (MTD) concept in oncology dose-finding trials.
Sign Up to like & getrecommendations! Published in 2017 at "F1000Research"
DOI: 10.12688/f1000research.10624.1
Abstract: Background. Absent adaptive, individualized dose-finding in early-phase oncology trials, subsequent 'confirmatory' Phase III trials risk suboptimal dosing, with resulting loss of statistical power and reduced probability of technical success for the investigational drug. While progress… read more here.
Keywords: concept; titration; dose finding; dose titration ... See more keywords