Preclinical Safety Evaluation: Acute and Repeated-Dose Toxicity of a New Intranasal Recombinant Vector Vaccine TB/FLU-04L Against Tuberculosis.
Sign Up to like & getrecommendations! Published in 2022 at "Drug research"
DOI: 10.1055/a-1771-5985
Abstract: BACKGROUND Vaccination against tuberculosis is one of the most successful medical measures to reduce morbidity and mortality. The BCG vaccine has been in use for more than 100 years, but its efficacy is still controversial.… read more here.
Keywords: toxicity; toxicity study; flu 04l; dose toxicity ... See more keywords
Repeated dose toxicity studies of Trichostatin A in Swiss albino mice through oral and intravenous route of administration with special emphasis on genotoxicity
Sign Up to like & getrecommendations! Published in 2024 at "Drug and Chemical Toxicology"
DOI: 10.1080/01480545.2024.2336521
Abstract: Abstract Intravenous and oral 14 d repeated dose toxicity studies of Trichostatin A (TSA) were carried out in Swiss albino mice using low, intermediate, and high doses. Intravenous doses were 10, 25, and 50 μg/kg b.w while… read more here.
Keywords: repeated dose; dose toxicity; toxicity studies; administration ... See more keywords
Evaluation of acute and 28-day repeated dose toxicity of Tolypocladium sinense soft capsule in Sprague-Dawley rats
Sign Up to like & getrecommendations! Published in 2024 at "Drug and Chemical Toxicology"
DOI: 10.1080/01480545.2024.2427766
Abstract: Abstract Tolypocladium sinense is a new asexual strain isolated from natural Cordyceps sinensis. The mycelium produced by its fermentation culture has similar chemical components and pharmacological effects to C. sinensis. T. sinense soft capsule is… read more here.
Keywords: repeated dose; dose toxicity; soft capsules; toxicity ... See more keywords
Safety assessment of the Quercus brantii gall hydroalcoholic extract: Single and repeated oral dose toxicity studies.
Sign Up to like & getrecommendations! Published in 2022 at "Iranian journal of basic medical sciences"
DOI: 10.22038/ijbms.2022.65488.14418
Abstract: Objectives Quercus brantii galls (QBGs) are well-known in Iranian traditional medicine for treating various diseases. The aim of study was to assess the acute and repeated oral toxicity of the hydroalcoholic extract of QBG in… read more here.
Keywords: toxicity; hydroalcoholic extract; quercus brantii; dose toxicity ... See more keywords
StreptInCor, a Group A Streptococcal Adsorbed Vaccine: Evaluation of Repeated Intramuscular Dose Toxicity Testing in Rats
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.643317
Abstract: Streptococcus pyogenes infections continue to be a worldwide public health problem, causing various diseases in humans, with rheumatic fever and rheumatic heart disease being the most harmful manifestations. Impetigo and post-streptococcal glomerulonephritis are also important… read more here.
Keywords: dose toxicity; adsorbed vaccine; repeated intramuscular; streptincor ... See more keywords
Monte Carlo Models for Sub-Chronic Repeated-Dose Toxicity: Systemic and Organ-Specific Toxicity
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23126615
Abstract: The risk-characterization of chemicals requires the determination of repeated-dose toxicity (RDT). This depends on two main outcomes: the no-observed-adverse-effect level (NOAEL) and the lowest-observed-adverse-effect level (LOAEL). These endpoints are fundamental requirements in several regulatory frameworks,… read more here.
Keywords: systemic organ; organ specific; sub chronic; toxicity ... See more keywords