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   Articles with "dosing" as a keyword



De-escalated Teclistamab dosing in relapsed/refractory multiple myeloma: Czech myeloma group real-world evidence analysis

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recommendations! Published in 2025 at "Annals of Hematology"

DOI: 10.1007/s00277-025-06529-1

Abstract: Teclistamab, a BCMA×CD3 bispecific antibody, demonstrates high efficacy in relapsed/refractory multiple myeloma (RRMM). However, optimal dosing strategies outside clinical trials remain undefined. Thus, we performed a retrospective, multicentre analysis of 73 RRMM patients treated with… read more here.

Keywords: multiple myeloma; refractory multiple; dosing; relapsed refractory ... See more keywords

Antibiotic dosing adjustments in hospitalized patients with chronic kidney disease: a retrospective chart review

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recommendations! Published in 2021 at "International Urology and Nephrology"

DOI: 10.1007/s11255-021-02834-6

Abstract: Infections in patients with chronic kidney disease (CKD) are a major cause of hospitalization. The pharmacokinetics of renally eliminated antibiotics may lead to drug accumulation, resulting in potential toxicity. The renal dosing adjustment of antibiotics… read more here.

Keywords: antibiotic dosing; chronic kidney; patients chronic; retrospective chart ... See more keywords

Model-Optimized Fluconazole Dose Selection for Critically Ill Patients Improves Early Pharmacodynamic Target Attainment without the Need for Therapeutic Drug Monitoring

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recommendations! Published in 2020 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.02019-20

Abstract: Fluconazole has been associated with higher mortality compared with the echinocandins in patients treated for invasive candida infections. Underexposure from current fluconazole dosing regimens may contribute to these worse outcomes, so alternative dosing strategies require… read more here.

Keywords: drug; target attainment; model; dose selection ... See more keywords

4-Factor Prothrombin Complex Concentrate Dosing Strategies: A Retrospective Evaluation.

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recommendations! Published in 2022 at "Journal of pharmacy practice"

DOI: 10.1177/08971900221131924

Abstract: ObjectivesDetermine indication specific 4-Factor prothrombin complex concentrate (4FPCC) dosing strategies within a hospital system and subsequent effectiveness. Background: 4FPCC is FDA approved for reversal of vitamin K antagonists (VKA) for acute major bleeding or need… read more here.

Keywords: factor prothrombin; complex concentrate; dosing; dosing strategies ... See more keywords

Validation of a novel web-based application for hepatic arterial infusion floxuridine dosing.

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recommendations! Published in 2024 at "Journal of Clinical Oncology"

DOI: 10.1200/jco.2024.42.3_suppl.15

Abstract: 15 Background: Hepatic arterial infusion (HAI) floxuridine (FUDR) dosing is a complex, multifactorial process with weight-based dosing dependent on the fold change of aspartate aminotransferase, alkaline phosphatase, and total bilirubin relative to reference values from… read more here.

Keywords: oncology; hepatic arterial; arterial infusion; application ... See more keywords

Rodent Diets Incorporated with Live Biotherapeutic Products (LBPs): An Innovative Dosing Strategy to Support Preclinical Animal Studies on LBP Intervention

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recommendations! Published in 2025 at "AAPS PharmSciTech"

DOI: 10.1208/s12249-025-03050-6

Abstract: Currently, the administration of live biotherapeutic products (LBPs) in animal-based pre-clinical studies is achieved via oral gavage or voluntary consumption through the water supply. Oral gavage provides the most accurate and precise dosing for the… read more here.

Keywords: live biotherapeutic; products lbps; rodent diets; biotherapeutic products ... See more keywords

Ethnic Diversity and Warfarin Pharmacogenomics

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recommendations! Published in 2022 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2022.866058

Abstract: Warfarin has remained the most commonly prescribed vitamin K oral anticoagulant worldwide since its approval in 1954. Dosing challenges including having a narrow therapeutic window and a wide interpatient variability in dosing requirements have contributed… read more here.

Keywords: whites asians; dosing; diversity warfarin; ethnic diversity ... See more keywords