Antibiotic dosing adjustments in hospitalized patients with chronic kidney disease: a retrospective chart review
Sign Up to like & getrecommendations! Published in 2021 at "International Urology and Nephrology"
DOI: 10.1007/s11255-021-02834-6
Abstract: Infections in patients with chronic kidney disease (CKD) are a major cause of hospitalization. The pharmacokinetics of renally eliminated antibiotics may lead to drug accumulation, resulting in potential toxicity. The renal dosing adjustment of antibiotics… read more here.
Keywords: antibiotic dosing; chronic kidney; patients chronic; retrospective chart ... See more keywords
Model-Optimized Fluconazole Dose Selection for Critically Ill Patients Improves Early Pharmacodynamic Target Attainment without the Need for Therapeutic Drug Monitoring
Sign Up to like & getrecommendations! Published in 2020 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02019-20
Abstract: Fluconazole has been associated with higher mortality compared with the echinocandins in patients treated for invasive candida infections. Underexposure from current fluconazole dosing regimens may contribute to these worse outcomes, so alternative dosing strategies require… read more here.
Keywords: drug; target attainment; model; dose selection ... See more keywords
4-Factor Prothrombin Complex Concentrate Dosing Strategies: A Retrospective Evaluation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmacy practice"
DOI: 10.1177/08971900221131924
Abstract: ObjectivesDetermine indication specific 4-Factor prothrombin complex concentrate (4FPCC) dosing strategies within a hospital system and subsequent effectiveness. Background: 4FPCC is FDA approved for reversal of vitamin K antagonists (VKA) for acute major bleeding or need… read more here.
Keywords: factor prothrombin; complex concentrate; dosing; dosing strategies ... See more keywords
Ethnic Diversity and Warfarin Pharmacogenomics
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DOI: 10.3389/fphar.2022.866058
Abstract: Warfarin has remained the most commonly prescribed vitamin K oral anticoagulant worldwide since its approval in 1954. Dosing challenges including having a narrow therapeutic window and a wide interpatient variability in dosing requirements have contributed… read more here.
Keywords: whites asians; dosing; diversity warfarin; ethnic diversity ... See more keywords