Precision dosing‐based optimisation of paroxetine during pregnancy for poor and ultrarapid CYP2D6 metabolisers: a virtual clinical trial pharmacokinetics study
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DOI: 10.1111/jphp.13281
Abstract: Paroxetine has been demonstrated to undergo gestation‐related reductions in plasma concentrations, to an extent which is dictated by the polymorphic state of CYP 2D6. However, knowledge of appropriate dose titrations is lacking. read more here.
Keywords: paroxetine pregnancy; dosing based; optimisation paroxetine; precision dosing ... See more keywords
Rivaraoxaban dosing is based on more than just pharmacokinetic properties
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DOI: 10.1136/bmj.j608
Abstract: We at Bayer think that Moore’s letter on rivaroxaban is misleading.1 Pharmacokinetic properties are not the sole determinants of the appropriate dosing regimen, and the pharmacodynamic effect of rivaroxaban once daily is evident for the… read more here.
Keywords: pharmacokinetic properties; based pharmacokinetic; dosing based; rivaraoxaban dosing ... See more keywords
Exploration of an Association Between UFH Dosing Based on Estimated Blood Volume and Venous Thromboembolism and Bleeding in the Underweight and Critically Ill
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DOI: 10.1177/1060028020909388
Abstract: We undertook a post hoc analysis of study data published in the journal to further investigate the association between bleeding risk and the use of venous thromboembolism (VTE) prophylaxis in underweight, critically ill patients and… read more here.
Keywords: vte; underweight critically; dosing based; ufh dosing ... See more keywords