Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia-A comprehensive review.
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DOI: 10.1002/bcp.70317
Abstract: While the event-free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under… read more here.
Keywords: developmental changes; acute lymphoblastic; used treatment; lymphoblastic leukaemia ... See more keywords
#2846 Comparison of three different amikacin guidelines for pediatric patients: virtual population insight
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DOI: 10.1093/ndt/gfaf116.2004
Abstract: Amikacin, a key aminoglycoside for treating severe pediatric infections, requires precise dosing to achieve therapeutic efficacy while minimizing nephrotoxic risks. Effective treatment depends on achieving high peak concentrations (20–80 mg/L) to ensure bacterial eradication and… read more here.
Keywords: treatment; trough levels; pediatric patients; amikacin ... See more keywords
Antithrombin Dosing Guidelines in Children Underestimate Dose Needed for Plasma Level Increase
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DOI: 10.1097/pcc.0000000000002383
Abstract: Objectives: Antithrombin is a cofactor in the coagulation cascade with mild anticoagulant activity and facilitates the action of heparin as an anticoagulant. Antithrombin concentrate dosing guidelines vary but most commonly suggest that each unit of… read more here.
Keywords: concentrate; dosing guidelines; level; increase ... See more keywords
Comment on Delanaye et al: Future perspectives regarding kidney function estimates and dose adjustments
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DOI: 10.1111/bcp.15195
Abstract: observational indicate prescribing is approximately of all of and hospitalizations. About 40% of all should be according to renal function, 2 and a Swedish study concluded that one third of all adverse drug reactions leading… read more here.
Keywords: function; kidney function; dosing guidelines; comment delanaye ... See more keywords
Pharmacogenomic-guided dosing of fluoropyrimidines beyond DPYD: time for a polygenic algorithm?
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DOI: 10.3389/fphar.2023.1184523
Abstract: Fluoropyrimidines are chemotherapeutic agents widely used for the treatment of various solid tumors. Commonly prescribed FPs include 5-fluorouracil (5-FU) and its oral prodrugs capecitabine (CAP) and tegafur. Bioconversion of 5-FU prodrugs to 5-FU and subsequent… read more here.
Keywords: guided dosing; toxicity; beyond dpyd; dosing guidelines ... See more keywords