Antithrombin Dosing Guidelines in Children Underestimate Dose Needed for Plasma Level Increase
Sign Up to like & getrecommendations! Published in 2020 at "Pediatric Critical Care Medicine"
DOI: 10.1097/pcc.0000000000002383
Abstract: Objectives: Antithrombin is a cofactor in the coagulation cascade with mild anticoagulant activity and facilitates the action of heparin as an anticoagulant. Antithrombin concentrate dosing guidelines vary but most commonly suggest that each unit of… read more here.
Keywords: concentrate; dosing guidelines; level; increase ... See more keywords
Comment on Delanaye et al: Future perspectives regarding kidney function estimates and dose adjustments
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.15195
Abstract: observational indicate prescribing is approximately of all of and hospitalizations. About 40% of all should be according to renal function, 2 and a Swedish study concluded that one third of all adverse drug reactions leading… read more here.
Keywords: function; kidney function; dosing guidelines; comment delanaye ... See more keywords
Pharmacogenomic-guided dosing of fluoropyrimidines beyond DPYD: time for a polygenic algorithm?
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1184523
Abstract: Fluoropyrimidines are chemotherapeutic agents widely used for the treatment of various solid tumors. Commonly prescribed FPs include 5-fluorouracil (5-FU) and its oral prodrugs capecitabine (CAP) and tegafur. Bioconversion of 5-FU prodrugs to 5-FU and subsequent… read more here.
Keywords: guided dosing; toxicity; beyond dpyd; dosing guidelines ... See more keywords