Dosing Recommendation Based on the Effects of Different Meal Types on Pexidartinib Pharmacokinetics in Healthy Subjects: Implementation of Model‐informed Drug Development Strategy
Sign Up to like & getrecommendations! Published in 2023 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1240
Abstract: Pexidartinib, an oral small molecule inhibitor of the colony‐stimulating factor 1 receptor, is approved for treatment of adults with symptomatic tenosynovial giant cell tumor associated with severe morbidity or functional limitations and not amenable to… read more here.
Keywords: meal; low fat; dosing regimen; fat meal ... See more keywords
Innovative Randomized Phase I Study and Dosing Regimen Selection to Accelerate and Inform Pivotal COVID‐19 Trial of Nirmatrelvir
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2603
Abstract: Coronavirus disease 2019 (COVID‐19) is a continued leading cause of hospitalization and death. Safe, efficacious COVID‐19 antivirals are needed urgently. Nirmatrelvir (PF‐07321332), the first orally bioavailable, severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) Mpro inhibitor against… read more here.
Keywords: phase; pharmacology; dosing regimen; nirmatrelvir ritonavir ... See more keywords
OptiDose: Computing the Individualized Optimal Drug Dosing Regimen Using Optimal Control
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Optimization Theory and Applications"
DOI: 10.1007/s10957-021-01819-w
Abstract: Providing the optimal dosing strategy of a drug for an individual patient is an important task in pharmaceutical sciences and daily clinical application. We developed and validated an optimal dosing algorithm (OptiDose) that computes the… read more here.
Keywords: control; control problem; drug; pharmacokinetic pharmacodynamic ... See more keywords
Pharmacokinetics and Pharmacodynamics of Levornidazole in Patients With Intra-abdominal AnaerobicInfection.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2018.07.017
Abstract: PURPOSE The pharmacokinetic (PK) and pharmacodynamic characteristics of levornidazole were studied in patients with intra-abdominal anaerobic infection to provide the rationale of new clinical dosing regimen of levornidazole. METHODS A single-center, open, multidose trial was… read more here.
Keywords: abdominal anaerobic; 500mg q12h; anaerobic infection; dosing regimen ... See more keywords
Population pharmacokinetics and dosing optimization of latamoxef in neonates and young infants.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2018.11.017
Abstract: OBJECTIVES There has been recent renewed interest in historical antibiotics because of the increased antibiotic-resistant bacterial strains. Latamoxef, a semi-synthetic oxacephem antibiotic developed in 1980s, has recently been brought back into use for treatment of… read more here.
Keywords: latamoxef neonates; latamoxef; neonates young; young infants ... See more keywords
EMICIZUMAB DOSING IN CHILDREN AND ADULTS WITH HEMOPHILIA A: SIMULATING A USER-FRIENDLY AND COST-EFFICIENT REGIMEN.
Sign Up to like & getrecommendations! Published in 2021 at "Thrombosis and haemostasis"
DOI: 10.1055/a-1499-0030
Abstract: BACKGROUND When emicizumab is dosed according to label, clinicians are obligated to discard or overdose medication due to discrepancies between calculated dose and vial content. The aim of this study was to compose a cost-efficient… read more here.
Keywords: emicizumab dosing; cost; alternative dosing; cost efficient ... See more keywords
Methotrexate dosing regimen for plaque-type psoriasis: an update of a systematic review
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Dermatological Treatment"
DOI: 10.1080/09546634.2022.2117539
Abstract: Abstract Background Methotrexate (MTX) is a systemic treatment for plaque-type psoriasis. At the time of approval, no dose-ranging studies were performed. Nowadays, a uniform dosing regimen is lacking. This might contribute to suboptimal treatment with… read more here.
Keywords: type psoriasis; plaque type; mtx; dosing regimen ... See more keywords
Fixed dosing of kukoamine B in sepsis patients: Results from population pharmacokinetic modelling and simulation.
Sign Up to like & getrecommendations! Published in 2022 at "British journal of clinical pharmacology"
DOI: 10.1111/bcp.15342
Abstract: AIMS To assess the appropriateness of the bodyweight or fixed dosing regimen, population pharmacokinetic (PopPK) model of kukoamine B has been built in sepsis patients. METHODS Plasma Concentrations of kukoamine B and the covariates information… read more here.
Keywords: fixed dosing; model; dosing regimen; simulation ... See more keywords
Evening versus morning dosing regimen drug therapy for chronic kidney disease patients with hypertension in blood pressure patterns: a systematic review and meta‐analysis
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DOI: 10.1111/imj.13490
Abstract: Evening dosing regimen drug therapy on blood pressure (BP) control is used widely, but its clinical benefits and preservation or re‐establishment of the normal 24‐h BP dipping pattern in chronic kidney disease (CKD) patients is… read more here.
Keywords: drug therapy; chronic kidney; blood pressure; regimen drug ... See more keywords
Pharmacokinetic-pharmacodynamic modelling for the determination of optimal dosing regimen of florfenicol in Nile tilapia (Oreochromis niloticus) at different water temperatures and antimicrobial susceptibility levels.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of fish diseases"
DOI: 10.1111/jfd.13040
Abstract: Optimized dosing regimen is key to the effective use of antibacterials and to minimizing drug-related side effects. The current study established a pharmacokinetic-pharmacodynamic (PK-PD) model for the determination of optimal antibacterial dosing regimen in fish… read more here.
Keywords: antimicrobial susceptibility; determination optimal; pharmacokinetic pharmacodynamic; tilapia ... See more keywords
Model-Oriented Dose Optimization of Voriconazole in Critically Ill Children
Sign Up to like & getrecommendations! Published in 2021 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00493-21
Abstract: This study aimed to employ a population pharmacokinetic (PK) model to optimize the dosing regimen of voriconazole (VRC) in children with a critical illness. A total of 99 children aged from 0.44 to 13.58 years were… read more here.
Keywords: critically ill; study; model; ill children ... See more keywords