Dosing Recommendation Based on the Effects of Different Meal Types on Pexidartinib Pharmacokinetics in Healthy Subjects: Implementation of Model‐informed Drug Development Strategy
Sign Up to like & getrecommendations! Published in 2023 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1240
Abstract: Pexidartinib, an oral small molecule inhibitor of the colony‐stimulating factor 1 receptor, is approved for treatment of adults with symptomatic tenosynovial giant cell tumor associated with severe morbidity or functional limitations and not amenable to… read more here.
Keywords: meal; low fat; dosing regimen; fat meal ... See more keywords
Innovative Randomized Phase I Study and Dosing Regimen Selection to Accelerate and Inform Pivotal COVID‐19 Trial of Nirmatrelvir
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2603
Abstract: Coronavirus disease 2019 (COVID‐19) is a continued leading cause of hospitalization and death. Safe, efficacious COVID‐19 antivirals are needed urgently. Nirmatrelvir (PF‐07321332), the first orally bioavailable, severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) Mpro inhibitor against… read more here.
Keywords: phase; pharmacology; dosing regimen; nirmatrelvir ritonavir ... See more keywords
Optimal Dosing Regimen for Epcoritamab, a Subcutaneous Bispecific Antibody, in Relapsed or Refractory Large B‐Cell Lymphoma
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.3588
Abstract: Epcoritamab is a CD3xCD20 bispecific antibody that activates T cells to kill CD20‐expressing B cells. Epcoritamab is approved for the treatment of adults with different types of relapsed or refractory lymphoma in various geographies, including… read more here.
Keywords: relapsed refractory; cell lymphoma; dosing regimen; large cell ... See more keywords
OptiDose: Computing the Individualized Optimal Drug Dosing Regimen Using Optimal Control
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Optimization Theory and Applications"
DOI: 10.1007/s10957-021-01819-w
Abstract: Providing the optimal dosing strategy of a drug for an individual patient is an important task in pharmaceutical sciences and daily clinical application. We developed and validated an optimal dosing algorithm (OptiDose) that computes the… read more here.
Keywords: control; control problem; drug; pharmacokinetic pharmacodynamic ... See more keywords
Model-Informed Development of a Cost-Saving Dosing Regimen for Sacituzumab Govitecan
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DOI: 10.1007/s11523-024-01075-8
Abstract: The antibody–drug conjugate sacituzumab govitecan is approved for metastatic triple-negative breast cancer and has shown promising results in various other types of cancer. Its costs may limit patient access to this novel effective treatment modality.… read more here.
Keywords: dosing regimen; sacituzumab govitecan; drug; model ... See more keywords
Pharmacokinetics and Pharmacodynamics of Levornidazole in Patients With Intra-abdominal AnaerobicInfection.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2018.07.017
Abstract: PURPOSE The pharmacokinetic (PK) and pharmacodynamic characteristics of levornidazole were studied in patients with intra-abdominal anaerobic infection to provide the rationale of new clinical dosing regimen of levornidazole. METHODS A single-center, open, multidose trial was… read more here.
Keywords: abdominal anaerobic; 500mg q12h; anaerobic infection; dosing regimen ... See more keywords
Population pharmacokinetics and dosing optimization of latamoxef in neonates and young infants.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2018.11.017
Abstract: OBJECTIVES There has been recent renewed interest in historical antibiotics because of the increased antibiotic-resistant bacterial strains. Latamoxef, a semi-synthetic oxacephem antibiotic developed in 1980s, has recently been brought back into use for treatment of… read more here.
Keywords: latamoxef neonates; latamoxef; neonates young; young infants ... See more keywords
EMICIZUMAB DOSING IN CHILDREN AND ADULTS WITH HEMOPHILIA A: SIMULATING A USER-FRIENDLY AND COST-EFFICIENT REGIMEN.
Sign Up to like & getrecommendations! Published in 2021 at "Thrombosis and haemostasis"
DOI: 10.1055/a-1499-0030
Abstract: BACKGROUND When emicizumab is dosed according to label, clinicians are obligated to discard or overdose medication due to discrepancies between calculated dose and vial content. The aim of this study was to compose a cost-efficient… read more here.
Keywords: emicizumab dosing; cost; alternative dosing; cost efficient ... See more keywords
Methotrexate dosing regimen for plaque-type psoriasis: an update of a systematic review
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Dermatological Treatment"
DOI: 10.1080/09546634.2022.2117539
Abstract: Abstract Background Methotrexate (MTX) is a systemic treatment for plaque-type psoriasis. At the time of approval, no dose-ranging studies were performed. Nowadays, a uniform dosing regimen is lacking. This might contribute to suboptimal treatment with… read more here.
Keywords: type psoriasis; plaque type; mtx; dosing regimen ... See more keywords
Potential serotype-specific effectiveness against IPD of pneumococcal conjugate vaccines V114 and PCV20 in children given a 2+1 dosing regimen
Sign Up to like & getrecommendations! Published in 2024 at "Expert Review of Vaccines"
DOI: 10.1080/14760584.2024.2335323
Abstract: ABSTRACT Background Next generation, higher valency pneumococcal conjugate vaccines (PCVs) are assessed and licensed by comparing the immune response across serotypes shared with the PCVs that are standard of care for prevention of pneumococcal disease.… read more here.
Keywords: pneumococcal conjugate; serotype specific; conjugate vaccines; dosing regimen ... See more keywords
Fixed dosing of kukoamine B in sepsis patients: Results from population pharmacokinetic modelling and simulation.
Sign Up to like & getrecommendations! Published in 2022 at "British journal of clinical pharmacology"
DOI: 10.1111/bcp.15342
Abstract: AIMS To assess the appropriateness of the bodyweight or fixed dosing regimen, population pharmacokinetic (PopPK) model of kukoamine B has been built in sepsis patients. METHODS Plasma Concentrations of kukoamine B and the covariates information… read more here.
Keywords: fixed dosing; model; dosing regimen; simulation ... See more keywords