Comparing the Pharmacokinetics of 2 Novel Intravenous Tramadol Dosing Regimens to Oral Tramadol: A Randomized 3‐Arm Crossover Study
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DOI: 10.1002/cpdd.746
Abstract: Tramadol is a dual‐mechanism (opiate and monoamine reuptake inhibition) analgesic. Intravenous (IV) tramadol has been widely prescribed outside the United States. However, there have not been studies comparing the pharmacokinetics (PK) of IV dosing regimens… read more here.
Keywords: comparing pharmacokinetics; dosing regimens; crossover study; intravenous tramadol ... See more keywords
Impact of Dose Delays and Alternative Dosing Regimens on Pertuzumab Pharmacokinetics
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DOI: 10.1002/jcph.1855
Abstract: PERJETA (pertuzumab), administered with Herceptin (trastuzumab), is used in the treatment of human epidermal growth factor receptor 2‐positive breast cancer. Pertuzumab is currently approved with an initial loading dose of 840 mg, followed by a… read more here.
Keywords: impact dose; pertuzumab; dosing regimens; alternative dosing ... See more keywords
Valganciclovir Pharmacokinetics in Patients Receiving Oral Prophylaxis Following Kidney Transplantation and Model-Based Predictions of Optimal Dosing Regimens
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DOI: 10.1007/s40262-018-0638-5
Abstract: Background and ObjectivesValganciclovir is used as oral prophylaxis for cytomegalovirus (CMV) infection in kidney transplant recipients. However, limited pharmacokinetic data exist to guide dosing in this patient group. This study aimed to describe the population… read more here.
Keywords: kidney transplant; dosing regimens; model; oral prophylaxis ... See more keywords
Model-Informed Precision Dosing of Eculizumab in Patients with Paroxysmal Nocturnal Hemoglobinuria
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DOI: 10.1007/s40262-025-01536-x
Abstract: Eculizumab is an expensive therapeutic monoclonal antibody inhibiting complement C5 and approved for various indications, including the rare disease paroxysmal nocturnal hemoglobinuria. Eculizumab is administered in a “one-dose-fits-all” dosing paradigm in adults, which is inflexible… read more here.
Keywords: dosing regimens; paroxysmal nocturnal; patients paroxysmal; model ... See more keywords
Higher vs Standard Adalimumab Induction and Maintenance Dosing Regimens for Treatment of Ulcerative Colitis: SERENE UC Trial Results.
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DOI: 10.1053/j.gastro.2022.02.033
Abstract: BACKGROUND & AIMS SERENE UC evaluated the efficacy of higher adalimumab induction and maintenance dose regimens in patients with ulcerative colitis (UC). METHODS This phase 3, double-blind, randomized trial included induction and maintenance studies, with… read more here.
Keywords: adalimumab induction; dosing regimens; week; induction maintenance ... See more keywords
Optimization of dosing regimens of vancomycin, teicoplanin, linezolid and daptomycin against methicillin-resistant Staphylococcus aureus in neutropenic patients with cancer by Monte Carlo simulations
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DOI: 10.1080/1120009x.2021.1931758
Abstract: The objective of this study was to evaluate the efficacy of various dosing regimens of vancomycin, teicoplanin, linezolid and daptomycin against methicillin-resistant Staphylococcus aureus (MRSA) in neutropenic patients with cancer. Monte Carlo simulations were conducted… read more here.
Keywords: patients cancer; dosing regimens; regimens vancomycin; vancomycin teicoplanin ... See more keywords
Optimizing the dosing regimens of linezolid against gram-positive cocci in critically ill patients with different renal functions: a Monte Carlo simulation
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DOI: 10.1080/1120009x.2024.2440192
Abstract: Abstract To promote the accurate administration of linezolid, this study aimed to evaluate its dosage regimens in critically ill patients with varying renal functions. This evaluation was based on a combined analysis of pharmacokinetic (PK),… read more here.
Keywords: renal functions; ill patients; dosing regimens; renal impairment ... See more keywords
Efficacious dosing regimens for anti-TNF therapies in inflammatory bowel disease: where do we stand?
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DOI: 10.1080/14712598.2023.2198086
Abstract: ABSTRACT Introduction During the last decades, biologics have revolutionized the treatment of Crohn’s disease and ulcerative colitis. Even though the inflammatory bowel disease (IBD) armamentarium is rapidly expanding with novel biologics, anti-tumor necrosis factor (TNF)… read more here.
Keywords: dosing regimens; anti tnf; inflammatory bowel; bowel disease ... See more keywords
Intravenous fosfomycin for the treatment of multidrug-resistant pathogens: what is the evidence on dosing regimens?
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DOI: 10.1080/14787210.2019.1573669
Abstract: ABSTRACT Introduction: The intravenous (IV) formulation of fosfomycin has been re-introduced in clinical practice mainly to overcome treatment failures against multidrug-resistant (MDR) bacteria. Appropriate dosing schedules of the IV formulation have not yet been established.… read more here.
Keywords: treatment; dosing regimens; treatment multidrug; multidrug resistant ... See more keywords
Optimizing ganciclovir and valganciclovir dosing regimens in pediatric patients with cytomegalovirus infection: a spotlight on therapeutic drug monitoring.
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DOI: 10.1080/17512433.2023.2181161
Abstract: INTRODUCTION Infants and immunocompromised children with cytomegalovirus (CMV) infection have significant morbidity and mortality. Ganciclovir (GCV) and its oral prodrug valganciclovir (VGCV) are the major antiviral options of choice for the prophylaxis and treatment of… read more here.
Keywords: infection; drug monitoring; therapeutic drug; dosing regimens ... See more keywords
Therapeutic drug monitoring of carbapenem antibiotics in critically ill patients: an overview of principles, recommended dosing regimens and clinical outcomes.
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DOI: 10.1080/17512433.2023.2194629
Abstract: INTRODUCTION The importance of antibiotic treatment for sepsis in critically ill septic patients is well established. Consistently achieving the dose of antibiotic required to optimally kill bacteria, minimize the development of resistance, and avoid toxicity… read more here.
Keywords: ill patients; carbapenem antibiotics; critically ill; therapeutic drug ... See more keywords