Comparing the Pharmacokinetics of 2 Novel Intravenous Tramadol Dosing Regimens to Oral Tramadol: A Randomized 3‐Arm Crossover Study
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.746
Abstract: Tramadol is a dual‐mechanism (opiate and monoamine reuptake inhibition) analgesic. Intravenous (IV) tramadol has been widely prescribed outside the United States. However, there have not been studies comparing the pharmacokinetics (PK) of IV dosing regimens… read more here.
Keywords: comparing pharmacokinetics; dosing regimens; crossover study; intravenous tramadol ... See more keywords
Impact of Dose Delays and Alternative Dosing Regimens on Pertuzumab Pharmacokinetics
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Pharmacology"
DOI: 10.1002/jcph.1855
Abstract: PERJETA (pertuzumab), administered with Herceptin (trastuzumab), is used in the treatment of human epidermal growth factor receptor 2‐positive breast cancer. Pertuzumab is currently approved with an initial loading dose of 840 mg, followed by a… read more here.
Keywords: impact dose; pertuzumab; dosing regimens; alternative dosing ... See more keywords
Valganciclovir Pharmacokinetics in Patients Receiving Oral Prophylaxis Following Kidney Transplantation and Model-Based Predictions of Optimal Dosing Regimens
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DOI: 10.1007/s40262-018-0638-5
Abstract: Background and ObjectivesValganciclovir is used as oral prophylaxis for cytomegalovirus (CMV) infection in kidney transplant recipients. However, limited pharmacokinetic data exist to guide dosing in this patient group. This study aimed to describe the population… read more here.
Keywords: kidney transplant; dosing regimens; model; oral prophylaxis ... See more keywords
Higher vs Standard Adalimumab Induction and Maintenance Dosing Regimens for Treatment of Ulcerative Colitis: SERENE UC Trial Results.
Sign Up to like & getrecommendations! Published in 2022 at "Gastroenterology"
DOI: 10.1053/j.gastro.2022.02.033
Abstract: BACKGROUND & AIMS SERENE UC evaluated the efficacy of higher adalimumab induction and maintenance dose regimens in patients with ulcerative colitis (UC). METHODS This phase 3, double-blind, randomized trial included induction and maintenance studies, with… read more here.
Keywords: adalimumab induction; dosing regimens; week; induction maintenance ... See more keywords
Optimization of dosing regimens of vancomycin, teicoplanin, linezolid and daptomycin against methicillin-resistant Staphylococcus aureus in neutropenic patients with cancer by Monte Carlo simulations
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Chemotherapy"
DOI: 10.1080/1120009x.2021.1931758
Abstract: The objective of this study was to evaluate the efficacy of various dosing regimens of vancomycin, teicoplanin, linezolid and daptomycin against methicillin-resistant Staphylococcus aureus (MRSA) in neutropenic patients with cancer. Monte Carlo simulations were conducted… read more here.
Keywords: patients cancer; dosing regimens; regimens vancomycin; vancomycin teicoplanin ... See more keywords
Efficacious dosing regimens for anti-TNF therapies in inflammatory bowel disease: where do we stand?
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2023.2198086
Abstract: ABSTRACT Introduction During the last decades, biologics have revolutionized the treatment of Crohn’s disease and ulcerative colitis. Even though the inflammatory bowel disease (IBD) armamentarium is rapidly expanding with novel biologics, anti-tumor necrosis factor (TNF)… read more here.
Keywords: dosing regimens; anti tnf; inflammatory bowel; bowel disease ... See more keywords
Intravenous fosfomycin for the treatment of multidrug-resistant pathogens: what is the evidence on dosing regimens?
Sign Up to like & getrecommendations! Published in 2019 at "Expert Review of Anti-infective Therapy"
DOI: 10.1080/14787210.2019.1573669
Abstract: ABSTRACT Introduction: The intravenous (IV) formulation of fosfomycin has been re-introduced in clinical practice mainly to overcome treatment failures against multidrug-resistant (MDR) bacteria. Appropriate dosing schedules of the IV formulation have not yet been established.… read more here.
Keywords: treatment; dosing regimens; treatment multidrug; multidrug resistant ... See more keywords
Optimizing ganciclovir and valganciclovir dosing regimens in pediatric patients with cytomegalovirus infection: a spotlight on therapeutic drug monitoring.
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DOI: 10.1080/17512433.2023.2181161
Abstract: INTRODUCTION Infants and immunocompromised children with cytomegalovirus (CMV) infection have significant morbidity and mortality. Ganciclovir (GCV) and its oral prodrug valganciclovir (VGCV) are the major antiviral options of choice for the prophylaxis and treatment of… read more here.
Keywords: infection; drug monitoring; therapeutic drug; dosing regimens ... See more keywords
Therapeutic drug monitoring of carbapenem antibiotics in critically ill patients: an overview of principles, recommended dosing regimens and clinical outcomes.
Sign Up to like & getrecommendations! Published in 2023 at "Expert review of clinical pharmacology"
DOI: 10.1080/17512433.2023.2194629
Abstract: INTRODUCTION The importance of antibiotic treatment for sepsis in critically ill septic patients is well established. Consistently achieving the dose of antibiotic required to optimally kill bacteria, minimize the development of resistance, and avoid toxicity… read more here.
Keywords: ill patients; carbapenem antibiotics; critically ill; therapeutic drug ... See more keywords
An Evaluation Approach for the Performance of Dosing Regimens in Attention-Deficit/Hyperactivity Disorder Treatment.
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DOI: 10.1089/cap.2016.0108
Abstract: Abstract Objective: Stimulant medications, with methylphenidate as the main agent, are the most prescribed for the treatment of attention-deficit/hyperactivity disorder. Nevertheless, real challenges still remain for clinicians concerned with adaptation of the therapeutic regimens, in… read more here.
Keywords: treatment; deficit hyperactivity; dosing regimens; hyperactivity disorder ... See more keywords
Optimization of flucloxacillin dosing regimens in critically ill patients using population pharmacokinetic modelling of total and unbound concentrations
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DOI: 10.1093/jac/dkaa187
Abstract: Abstract Background Initial appropriate anti-infective therapy is associated with improved outcomes in patients with severe infections. In critically ill patients, altered pharmacokinetic (PK) behaviour is common and known to influence the achievement of PK/pharmacodynamic targets.… read more here.
Keywords: total unbound; unbound concentrations; ill patients; dosing regimens ... See more keywords