Isolation of the Dot/Icm Type IV Secretion System Core Complex from Legionella pneumophila.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9048-1_15
Abstract: Legionella utilizes specialized protein secretion machinery called the type IV secretion system encoded by dot/icm genes to modulate host cellular systems. We describe here the procedure to isolate the core complex of the Dot/Icm type… read more here.
Keywords: type secretion; dot icm; secretion; secretion system ... See more keywords
Contributions of lipopolysaccharide and the type IVB secretion system to Coxiella burnetii vaccine efficacy and reactogenicity
Sign Up to like & getrecommendations! Published in 2021 at "NPJ Vaccines"
DOI: 10.1038/s41541-021-00296-6
Abstract: Coxiella burnetii is the bacterial causative agent of the zoonosis Q fever. The current human Q fever vaccine, Q-VAX ® , is a fixed, whole cell vaccine (WCV) licensed solely for use in Australia. C.… read more here.
Keywords: phase; dot icm; reactogenicity; coxiella burnetii ... See more keywords
A Unique Cytoplasmic ATPase Complex Defines the Legionella pneumophila Type IV Secretion Channel
Sign Up to like & getrecommendations! Published in 2018 at "Nature microbiology"
DOI: 10.1038/s41564-018-0165-z
Abstract: Type IV secretion systems (T4SSs) are complex machines used by bacteria to deliver protein and DNA complexes into target host cells1–5. Conserved ATPases are essential for T4SS function, but how they coordinate their activities to… read more here.
Keywords: dot icm; secretion; legionella pneumophila; type secretion ... See more keywords
The Coxiella burnetii effector EmcB is a deubiquitinase that inhibits RIG-I signaling.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2217602120
Abstract: Eukaryotes have cytosolic surveillance systems to detect invading microorganisms and initiate protective immune responses. In turn, host-adapted pathogens have evolved strategies to modulate these surveillance systems, which can promote dissemination and persistence in the host.… read more here.
Keywords: surveillance; rig signaling; coxiella burnetii; dot icm ... See more keywords
The complete genome sequence of the crayfish pathogen Candidatus Paracoxiella cheracis n.g. n.sp. provides insight into pathogenesis and the phylogeny of the Coxiellaceae family
Sign Up to like & getrecommendations! Published in 2024 at "mSphere"
DOI: 10.1128/msphere.01002-24
Abstract: ABSTRACT The Coxiellaceae bacterial family, within the order Legionellales, is defined by a collection of poorly characterized obligate intracellular bacteria. The zoonotic pathogen and causative agent of human Q fever, Coxiella burnetii, represents the best-characterized… read more here.
Keywords: family; genome sequence; cheracis; dot icm ... See more keywords
In situ structure of the Legionella Dot/Icm type IV secretion system by electron cryotomography
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DOI: 10.15252/embr.201643598
Abstract: Type IV secretion systems (T4SSs) are large macromolecular machines that translocate protein and DNA and are involved in the pathogenesis of multiple human diseases. Here, using electron cryotomography (ECT), we report the in situ structure… read more here.
Keywords: dot icm; secretion; system; structure ... See more keywords
The Passage of Chaperonins to Extracellular Locations in Legionella pneumophila Requires a Functional Dot/Icm System
Sign Up to like & getrecommendations! Published in 2025 at "Biomolecules"
DOI: 10.3390/biom15010091
Abstract: HtpB, the chaperonin of the bacterial pathogen L. pneumophila, is found in extracellular locations, even the cytoplasm of host cells. Although chaperonins have an essential cytoplasmic function in protein folding, HtpB exits the cytoplasm to… read more here.
Keywords: icm system; extracellular locations; htpb; dot icm ... See more keywords