P101 DOT1L inhibition increases dermal fibroblast proliferation but has no effects on in vitro or in vivo collagen deposition in models of fibrosis
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-ewrr2018.117
Abstract: Introduction Fibrosis is a key process in Systemic Sclerosis, a devastating disease that is not well understood. The role of epigenetic disease mechanisms is increasingly explored. DOT1L, the unique H3K79-methyltransferase, methylates histone 3 at the… read more here.
Keywords: collagen; fibrosis; dot1l inhibition; proliferation ... See more keywords
DOT1L inhibition blocks multiple myeloma cell proliferation by suppressing IRF4-MYC signaling
Sign Up to like & getrecommendations! Published in 2018 at "Haematologica"
DOI: 10.3324/haematol.2018.191262
Abstract: Epigenetic alterations play an important role in the pathogenesis in multiple myeloma, but their biological and clinical relevance is not fully understood. Here, we show that DOT1L, which catalyzes methylation of histone H3 lysine 79,… read more here.
Keywords: multiple myeloma; cell; myeloma; dot1l inhibition ... See more keywords