Computer-Aided Discovery of Massonianoside B as a Novel Selective DOT1L Inhibitor.
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DOI: 10.1021/acschembio.8b00933
Abstract: Protein methyltransferases (PMTs) are involved in numerous biological processes and have been studied as a promising target class in the field of oncology and other diseases. Disruptor of telomeric silencing 1-like (DOT1L), a histone H3… read more here.
Keywords: massonianoside; dot1l inhibitor; discovery; mll ... See more keywords