Kinetic modelling of [68Ga]Ga-DOTA-Siglec-9 in a porcine infection model
Sign Up to like & getrecommendations! Published in 2018 at "Physica Medica"
DOI: 10.1016/j.ejmp.2018.06.404
Abstract: Purpose Localized infections deep in the body can be hard to diagnose. Positron emission tomography (PET) can scan inside the body, but depends on the availability of suitable tracers. The PET tracer [ 68 Ga]Ga-DOTA-Siglec-9… read more here.
Keywords: dota siglec; infection; tissue; model ... See more keywords
Safety Study of Single-Dose Intravenously Administered DOTA-Siglec-9 Peptide in Sprague Dawley Rats
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DOI: 10.1177/1091581818821606
Abstract: The peptide-based radioactive compound [68Ga]Ga-DOTA-Siglec-9 is a novel agent for imaging of inflammation with positron emission tomography. The drug target of [68Ga]Ga-DOTA-Siglec-9 is vascular adhesion protein 1. Previous studies have obtained promising results with [68Ga]Ga-DOTA-Siglec-9… read more here.
Keywords: siglec; dota siglec; single dose; study ... See more keywords
[68Ga]Ga-DOTA-Siglec-9 Detects Pharmacodynamic Changes of FAP-Targeted IL2 Variant Immunotherapy in B16-FAP Melanoma Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.901693
Abstract: Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible adhesion molecule, which supports contact between leukocytes and inflamed endothelium. There is evidence that VAP-1 is involved in the recruitment of leukocytes to melanoma tumors. Interleukin-2 (IL-2)-based immunotherapy… read more here.
Keywords: fap; fap il2v; dota siglec; 68ga dota ... See more keywords