Discovery of Dotinurad (FYU-981), a New Phenol Derivative with Highly Potent Uric Acid Lowering Activity.
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DOI: 10.1021/acsmedchemlett.0c00176
Abstract: To derive new uricosuric agents, novel phenol derivatives were synthesized to overcome the disadvantages of benzbromarone (BBR), attributed by its structural features. Herein, we report the discovery of new phenol derivatives with a 1,1-dioxo-1,2-dihydro-3H-1,3-benzothiazole scaffold.… read more here.
Keywords: uric acid; fyu 981; new phenol; dotinurad fyu ... See more keywords