Iridium-catalyzed asymmetric double allylic alkylation of azlactone: efficient access to chiral α-amino acid derivatives.
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DOI: 10.1039/d2cc00328g
Abstract: An unprecedented Ir-catalyzed enantioselective double allylic alkylation of less bulky cyclic imine glycinate (azlactone) was rationally designed and developed, providing various bisallylated chiral amino acid derivatives. Control experiments revealed that this transformation proceeds in a… read more here.
Keywords: chiral amino; amino acid; allylic alkylation; double allylic ... See more keywords