One-Pot Double-Annulation Strategy for the Synthesis of Unusual Fused Bis-Heterocycles.
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DOI: 10.1021/acs.orglett.0c01351
Abstract: A novel metal-free double-annulation cascade for the construction of unusual fused heterocyclic systems is described. This simple protocol enables the sequential assembly of two rings in one pot from two simple precursors. Acidic conditions promote… read more here.
Keywords: double annulation; unusual fused; strategy; one pot ... See more keywords
Double annulation of ortho- and peri-C–H bonds of fused (hetero)arenes to unusual oxepino-pyridines
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DOI: 10.1039/d0sc01373k
Abstract: Direct difunctionalization of chemically distinct ortho- and peri-C–H bonds of fused hetero(arenes) is illustrated through an unusual one-pot domino {[4 + 2] & [5 + 2]} double annulation with alkynes for the first time. This… read more here.
Keywords: annulation; double annulation; fused hetero; peri bonds ... See more keywords