Results of a randomized double‐blind study evaluating luvadaxistat in adults with Friedreich ataxia
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51373
Abstract: Friedreich ataxia (FRDA) is a rare disorder with progressive neurodegeneration and cardiomyopathy. Luvadaxistat (also known as TAK‐831; NBI‐1065844), an inhibitor of the enzyme d‐amino acid oxidase, has demonstrated beneficial effects in preclinical models relevant to… read more here.
Keywords: randomized double; luvadaxistat adults; friedreich ataxia; study ... See more keywords
A Randomized, Double‐Blind, Parallel Design Thorough QT Study With a Nested Crossover to Compare the Cardiac Safety of Amiselimod With Placebo and Positive Control in Healthy Volunteers
Sign Up to like & getrecommendations! Published in 2023 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1210
Abstract: This double‐blind study evaluated the cardiac safety of amiselimod. Healthy adults (n = 190) were randomized (2:1:1) to receive (1) oral placebo (day −1), followed by oral amiselimod (days 1–26), which was upwardly titrated from… read more here.
Keywords: cardiac safety; day; safety amiselimod; double blind ... See more keywords
Efficacy and safety of adjunctive padsevonil in adults with drug‐resistant focal epilepsy: Results from two double‐blind, randomized, placebo‐controlled trials
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia Open"
DOI: 10.1002/epi4.12656
Abstract: To characterize efficacy, safety/tolerability, and pharmacokinetics of padsevonil (PSL) administered concomitantly with ≤3 antiseizure medications (ASMs) for observable focal seizures in adults with drug‐resistant epilepsy in two multicenter, randomized, double‐blind, placebo‐controlled, parallel‐group trials. read more here.
Keywords: double blind; adults drug; placebo controlled; drug resistant ... See more keywords
Double‐blind randomized controlled trial of the routine perioperative use of terlipressin in adult living donor liver transplantation
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DOI: 10.1002/lt.24759
Abstract: Perioperative terlipressin (Tp) during living donor liver transplantation (LDLT) has been shown to reduce intraoperative portal pressures and improve renal function. Its role and safety profile have never been evaluated in a double‐blind randomized controlled… read more here.
Keywords: trial; infusion; transplantation; liver transplantation ... See more keywords
A Randomized, Double‐Blind, Controlled Phase II Study of Foliglurax in Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders"
DOI: 10.1002/mds.28970
Abstract: Agents targeting the metabotropic glutamate receptor 4 have emerged as a potentially attractive new class of drugs for the treatment of Parkinson's disease (PD). read more here.
Keywords: blind controlled; controlled phase; disease; parkinson disease ... See more keywords
Blonanserin vs risperidone in Japanese patients with schizophrenia: A post hoc analysis of a phase 3, 8‐week, multicenter, double‐blind, randomized controlled study
Sign Up to like & getrecommendations! Published in 2019 at "Neuropsychopharmacology Reports"
DOI: 10.1002/npr2.12089
Abstract: To report the efficacy and safety of blonanserin in patients with schizophrenia compared with risperidone in a Japanese multicenter, randomized, double‐blind study based on post hoc sensitivity analysis in addition to the previous results reported… read more here.
Keywords: post hoc; patients schizophrenia; risperidone japanese; study ... See more keywords
Efficacy and safety of adding fluoxetine to the treatment regimen of hospitalized patients with non-critical COVID-19 pneumonia: A double-blind randomized, placebo-controlled clinical trial.
Sign Up to like & getrecommendations! Published in 2023 at "Neuropsychopharmacology reports"
DOI: 10.1002/npr2.12327
Abstract: INTRODUCTION Selective serotonin reuptake inhibitors are considered the drugs, whose effectiveness in viral pandemics has been studied. The aim of this study was to evaluate of adding fluoxetine to the treatment regimen of patients with… read more here.
Keywords: covid pneumonia; adding fluoxetine; blind randomized; double blind ... See more keywords
A double‐blind, randomized, placebo‐controlled study to assess the efficacy of Andrographis paniculata standardized extract (ParActin®) on pain reduction in subjects with knee osteoarthritis
Sign Up to like & getrecommendations! Published in 2019 at "Phytotherapy Research"
DOI: 10.1002/ptr.6339
Abstract: Andrographis paniculata Wall (Acanthaceae) is becoming more recognized for its anti‐inflammatory and antioxidant properties. A randomized, double‐blind, placebo‐controlled study was conducted to assess the efficacy of an andrographolide‐containing supplement, ParActin® (300 and 600 mg daily),… read more here.
Keywords: reduction; paractin; andrographis paniculata; study ... See more keywords
The effect of (Cornus mas L.) fruit extract on liver function among patients with nonalcoholic fatty liver: A double‐blind randomized clinical trial
Sign Up to like & getrecommendations! Published in 2021 at "Phytotherapy Research"
DOI: 10.1002/ptr.7199
Abstract: This double‐blind randomized clinical trial aimed to investigate impact of Cornus mas L. fruit extract (CMFE) on liver function in nonalcoholic fatty liver disease (NAFLD). Fifty patients were randomly assigned into the CMFE and placebo… read more here.
Keywords: liver function; placebo; blind randomized; randomized clinical ... See more keywords
Traditional Vietnamese medicine Kovir capsule in patients with mild COVID‐19: A double‐blind randomized controlled trial
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7455
Abstract: Kovir capsule, a polyherbal medicine developed from Ren Shen Bai Du San formulation, has been used in various diseases including respiratory infections. A randomized, placebo‐controlled, double‐blind study was conducted to evaluate the safety and efficacy… read more here.
Keywords: time; double blind; mild covid; medicine ... See more keywords
Ulipristal acetate for Japanese women with symptomatic uterine fibroids: A double‐blind, randomized, phase II dose‐finding study
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12304
Abstract: A multicenter, randomized, double‐blind, placebo‐controlled trial was conducted to evaluate the efficacy, safety, and appropriate dose of ulipristal acetate (UPA) in Japanese women with symptomatic uterine fibroids (UFs). read more here.
Keywords: uterine fibroids; ulipristal acetate; japanese women; women symptomatic ... See more keywords