Plau/Plaur double-deficiency did not worsen lesion severity or vascular integrity after traumatic brain injury
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.134935
Abstract: Binding of urokinase-type plasminogen activator receptor (uPAR) to its ligand uPA or to its plasma membrane partner, platelet-derived growth factor receptor β (PDGFRβ), promotes neuroprotection, cell proliferation, and angiogenesis. Following injury, single deficiency in uPA… read more here.
Keywords: double deficiency; plaur; tbi; injury ... See more keywords
Double deficiency of toll-like receptors 2 and 4 alters long-term neurological sequelae in mice cured of pneumococcal meningitis
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DOI: 10.1038/s41598-019-52212-7
Abstract: Toll-like receptor (TLR) 2 and 4 signalling pathways are central to the body’s defence against invading pathogens during pneumococcal meningitis. Whereas several studies support their importance in innate immunity, thereby preventing host mortality, any role… read more here.
Keywords: pneumococcal meningitis; double deficiency; long term; mice ... See more keywords
PARP-1/PARP-2 double deficiency in mouse T cells results in faulty immune responses and T lymphomas
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DOI: 10.1038/srep41962
Abstract: The maintenance of T-cell homeostasis must be tightly regulated. Here, we have identified a coordinated role of Poly(ADP-ribose) polymerase-1 (PARP-1) and PARP-2 in maintaining T-lymphocyte number and function. Mice bearing a T-cell specific deficiency of… read more here.
Keywords: cell; immune responses; parp; double deficiency ... See more keywords