Spo11 generates gaps through concerted cuts at sites of topological stress.
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DOI: 10.1038/s41586-021-03632-x
Abstract: Meiotic recombination is essential for chromosome segregation at meiosis and fertility. It is initiated by programmed DNA double-strand breaks (DSBs) introduced by Spo11, a eukaryotic homologue of an archaeal topoisomerase (Topo VIA)1. Here we describe… read more here.
Keywords: topological stress; dna; double dsbs; double dsb ... See more keywords