Double hit & double expressor lymphomas: a multicenter analysis of survival outcomes with CD19-directed CAR T-cell therapy
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DOI: 10.1038/s41408-025-01250-8
Abstract: Double-hit (DHL) and double expressor (DEL) DLBCL have poor prognosis with standard therapy but CART may overcome this poor prognostic impact. In this multicenter retrospective study, we sought to confirm this observation by evaluating survival… read more here.
Keywords: cart; analysis; double hit; double expressor ... See more keywords
Gastrointestinal: Rapid emergence of double‐expressor lymphoma after Helicobacter pylori eradication therapy
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.15162
Abstract: A man in his 60s underwent esophagogastroduodenoscopy (EGD) because he found to be positive for serum Helicobacter pylori antibodies at a health checkup. He had no clinical symptoms. His grandparents had a history of gastric… read more here.
Keywords: eradication; lymphoma; eradication therapy; pylori eradication ... See more keywords
"Double-expressor" intravascular large B-cell lymphoma involving the female genital tract.
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DOI: 10.1182/blood-2018-03-839001
Abstract: ![Figure][1] A 43-year-old woman was admitted with chronic pelvic pain and unexplained fever. Her laboratory findings were notable for anemia (hemoglobin, 10.6 g/dL). No masses were detected by pelvic ultrasound. She underwent a total abdominal… read more here.
Keywords: expressor intravascular; lymphoma involving; intravascular large; large cell ... See more keywords
Rituximab, Chidamide, and Zanubrutinib±CHOP Could be a Promising Regimen for Newly Diagnosed Double-Expressor DLBCL (DE DLBCL)
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DOI: 10.1182/blood-2024-202818
Abstract: Background: DLBCL patients with co-expression of MYC (≥40%) and BCL2(≥50%) by immunohistochemistry are considered as double expressor lymphomas (DE DLBCL). The prognosis of DE DLBCL is usually worse than non-DE DLBCL. The Smart Start trial… read more here.
Keywords: chop; rcz chop; dlbcl; newly diagnosed ... See more keywords
Outcomes of patients with relapsed/refractory double-expressor B-cell lymphoma treated with ibrutinib monotherapy.
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DOI: 10.1182/bloodadvances.2018026401
Abstract: The B-cell receptor signaling pathway is active in diffuse large B-cell lymphomas, with increased expression of MYC and BCL2 protein. The overall response rate was 60% for relapsed/refractory non–germinal center double-expressor lymphoma patients treated with… read more here.
Keywords: relapsed refractory; cell; treated ibrutinib; double expressor ... See more keywords
Multimodality imaging for early diagnosis and treatment of primary cardiac diffuse 'double-expressor' lymphoma.
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DOI: 10.2459/jcm.0000000000000847
Abstract: : Primary cardiac double-expressor lymphoma represents a rare subtype of diffuse large B-cell lymphoma, especially in immunocompetent patients. To date, only a few sporadic cases of primary cardiac double-expressor lymphoma have been reported in medical… read more here.
Keywords: multimodality imaging; lymphoma; double expressor; primary cardiac ... See more keywords
Case Report: Concurrent Occurrence of Abdominal Double Expressor Lymphoma and Jejunum Follicular Lymphoma
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DOI: 10.3389/fonc.2021.656219
Abstract: Double expressor lymphoma (DEL), defined as overexpression of BCL2 and MYC, is an aggressive subtype of diffuse large B cell lymphoma (DLBCL). Here we report a case of a 64-year-old female diagnosed with abdominal DEL… read more here.
Keywords: lymphoma; del; expressor lymphoma; case ... See more keywords
An immunohistochemical study of double-expressor lymphomas and its correlation with cell of origin
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cancer Research and Therapeutics"
DOI: 10.4103/jcrt.jcrt_587_21
Abstract: Background: Diffuse large B cell Lymphomas (DLBCL) that co express C MYC and BCL 2 are known as 'double expressor lymphomas' and are believed to have a worse prognosis than other diffuse large B cell… read more here.
Keywords: cell; expressor lymphomas; double expressor; lymphomas ... See more keywords