“Double hit” anaplastic large cell lymphoma with concurrent ALK and MYC rearrangements
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DOI: 10.1002/ajh.25980
Abstract: A 28-year-old man presented with a history of persistent left groin swelling for 2 years, which has shown slow growth in recent 2 months. He denied any B symptoms including fever, night sweats, and weight… read more here.
Keywords: lymphoma; double hit; image; alk ... See more keywords
Double hit and double expressors in lymphoma: Definition and treatment
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DOI: 10.1002/cncr.31646
Abstract: Emerging biologic subsets and new prognostic markers are significantly and adversely affecting curability after standard chemoimmunotherapy for aggressive B‐cell lymphomas. The identification of concurrent MYC and B‐cell CLL/lymphoma 2 (BCL2) deregulation, whether at a genomic… read more here.
Keywords: lymphoma; double hit; cell lymphomas; hit double ... See more keywords
Double‐hit lymphoma: So what?
Sign Up to like & getrecommendations! Published in 2019 at "Hematological Oncology"
DOI: 10.1002/hon.2581
Abstract: The revised WHO classification moved all aggressive B‐cell lymphomas with a MYC translocation and a concurrent translocation of BCL2 and/or BCL6 into a single diagnostic category. These are the double‐ and triple‐hit lymphomas. These represent… read more here.
Keywords: hit lymphoma; double hit; oncology; biology ... See more keywords
Double-hit scenario of Covid-19 and global value chains
Sign Up to like & getrecommendations! Published in 2020 at "Environment, Development and Sustainability"
DOI: 10.1007/s10668-020-00982-w
Abstract: Due to the Covid-19 pandemic, labor force is greatly confined by quarantine (social distancing), and limited units of labor and capital are available at the workplace. Millions of employees have lost their jobs and are… read more here.
Keywords: double hit; covid global; covid; hit scenario ... See more keywords
Double-Hit Large B Cell Lymphoma
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DOI: 10.1007/s11912-017-0629-y
Abstract: Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL), accounting for approximately 25% of NHL cases. It is a heterogeneous group of diseases. BCL2, BCL6, and MYC are the… read more here.
Keywords: lymphoma; double hit; treatment; large cell ... See more keywords
A double-hit in vivo model of GBA viral microRNA-mediated downregulation and human alpha-synuclein overexpression demonstrates nigrostriatal degeneration
Sign Up to like & getrecommendations! Published in 2022 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2022.105612
Abstract: Preclinical and clinical studies support a strong association between mutations in the GBA1 gene that encodes beta-glucocerebrosidase (GCase) (EC 3.2.1.45; glucosylceramidase beta) and Parkinson's disease (PD). Alpha-synuclein (AS), a key player in PD pathogenesis, and… read more here.
Keywords: double hit; overexpression; alpha synuclein; downregulation ... See more keywords
Perspectives on chemotherapy for the management of double-hit lymphoma
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2020.1727445
Abstract: ABSTRACT Introduction Double-hit (DHL) and triple-hit lymphomas (THL) have long been among the most clinically aggressive molecular subtypes of diffuse large B-cell lymphomas. In the 2016 revised WHO classification, they represent a new entity called… read more here.
Keywords: lymphoma; double hit; perspectives chemotherapy; chemotherapy management ... See more keywords
Current perspectives on the treatment of double hit lymphoma
Sign Up to like & getrecommendations! Published in 2019 at "Expert Review of Hematology"
DOI: 10.1080/17474086.2019.1623020
Abstract: ABSTRACT Introduction: Double hit lymphoma (DHL) represents a new diagnostic category with genetic, immunohistochemical and clinical characteristics intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma. Patients with DHL usually experience poor survival after frontline… read more here.
Keywords: lymphoma; double hit; treatment; hit lymphoma ... See more keywords
Double-Hit and Triple-Hit Follicular Lymphoma.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of clinical pathology"
DOI: 10.1093/ajcp/aqz208
Abstract: OBJECTIVES To better characterize the clinicopathologic presentation and outcomes of follicular lymphoma with MYC and BCL2 and/or BCL6 rearrangements (double-hit and triple-hit follicular lymphoma), we present three cases from our institution and perform a literature… read more here.
Keywords: lymphoma; triple hit; double hit; follicular lymphoma ... See more keywords
Somatic double-hit in MTOR and RPS6 in hemimegalencephaly with intractable epilepsy.
Sign Up to like & getrecommendations! Published in 2019 at "Human molecular genetics"
DOI: 10.1093/hmg/ddz194
Abstract: Single germline or somatic activating mutations of mTOR pathway genes are emerging as a major cause of Type II Focal Cortical Dysplasia (FCD), hemimegalencephaly (HME), and Tuberous Sclerosis Complex (TSC). A double hit mechanism, based… read more here.
Keywords: double hit; hemimegalencephaly; rps6; mtor ... See more keywords
Immunohistochemical double hit score enhances NCCN–IPI and is associated with detrimental outcomes in refractory or relapsing patients with diffuse large B cell lymphoma
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Haematology"
DOI: 10.1111/bjh.14912
Abstract: atic review. Transfusion Medicine Reviews, 32, 173–182. Malara, A., Abbonante, V., Di Buduo, C.A., Tozzi, L., Currao, M. & Balduini, A. (2015) The secret life of a megakaryocyte: emerging roles in bone marrow homeostasis control.… read more here.
Keywords: medicine; double hit; hematopoietic stem; cell ... See more keywords