Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2109093119
Abstract: Significance Bloom syndrome complex (BS complex) is necessary for maintenance of genome stability and suppression of cancer-causing mutations. Composed of a helicase, a topoisomerase, and two scaffolds, the BS complex is implicated in several steps… read more here.
Keywords: dissolution; bloom syndrome; syndrome; double holliday ... See more keywords
Generation of double Holliday junction DNAs and their dissolution/resolution within a chromatin context
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123420119
Abstract: Significance We devised a method involving DNAzyme self-cleavage for the preparation of DNA molecules containing double Holliday junctions (dHJs) that are separated by 746 bp. The DNAs can be prepared in large amounts suitable for… read more here.
Keywords: generation double; holliday junction; junction dnas; resolution ... See more keywords