A Double‐Humanized Murine Model in Bladder Cancer: A Novel Preclinical Model for Cancer Immunology Research
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Medicine"
DOI: 10.1002/cam4.71150
Abstract: Bladder cancer (BC) ranks as the 10th leading cause of cancer‐related deaths in the United States. Despite significant advancements in managing BC, including antibody‐drug conjugates and immune checkpoint blockers, a significant percentage of patients fail… read more here.
Keywords: cancer; immunology; model; bladder cancer ... See more keywords
Abstract 5199: B7-H3 & PD-L1 double-humanized BALB/c mouse: a novel animal model for preclinical studies of human B7-H3 antibodies or bispecific antibodies
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5199
Abstract: Immune checkpoint molecule B7-H3, also known as CD276, is a member of the B7-CD28 family of immunomodulatory proteins. It is a type I membrane protein with sequence similarities to the extracellular domain of programmed death-ligand… read more here.
Keywords: double humanized; bispecific antibodies; mouse; antibodies bispecific ... See more keywords
A Double-Humanized Mouse Model for Studying Host Gut Microbiome–Immune Interactions in Gulf War Illness
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25116093
Abstract: Unraveling the multisymptomatic Gulf War Illness (GWI) pathology and finding an effective cure have eluded researchers for decades. The chronic symptom persistence and limitations for studying the etiologies in mouse models that differ significantly from… read more here.
Keywords: gwi; gulf war; pathology; model ... See more keywords