4E‐BP1 and 4E‐BP2 double knockout mice are protected from aging‐associated sarcopenia
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12412
Abstract: Sarcopenia is the loss of muscle mass/function that occurs during the aging process. The links between mechanistic target of rapamycin (mTOR) activity and muscle development are largely documented, but the role of its downstream targets… read more here.
Keywords: bp2 double; bp1 bp2; muscle; knockout mice ... See more keywords
Surprising outcomes in cannabinoid CB1/CB2 receptor double knockout mice in two models of ischemia
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.12.030
Abstract: Aims: We tested the hypothesis that CB1/CB2 receptor double knockout would produce significant increases in infarct size and volume and significant worsening in clinical score, using two mouse models, one of permanent ischemia and one… read more here.
Keywords: knockout mice; double knockout; receptor; cb1 cb2 ... See more keywords
Downregulation of Cyp7a1 by Cholic Acid and Chenodeoxycholic Acid in Cyp27a1/ApoE Double Knockout Mice: Differential Cardiovascular Outcome
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2020.586980
Abstract: Sterol 27-hydroxylase (CYP27A1) is a key enzyme in bile acids (BAs) biosynthesis and a regulator of cholesterol metabolism. Cyp27a1/Apolipoprotein E double knockout (DKO) mice fed with western diet (WD) are protected from atherosclerosis via up-regulation… read more here.
Keywords: dko mice; cholic acid; cholesterol; acid chenodeoxycholic ... See more keywords
Single Cell Sequencing Reveals Mechanisms of Persistent Truncus Arteriosus Formation after PDGFRα and PDGFRβ Double Knockout in Cardiac Neural Crest Cells
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13101708
Abstract: Persistent truncus arteriosus (PTA) is an uncommon and complex congenital cardiac malformation accounting for about 1.2% of all congenital heart diseases (CHDs), which is caused by a deficiency in the embryonic heart outflow tract’s (OFT)… read more here.
Keywords: cell; pdgfr double; pdgfr; pdgfr pdgfr ... See more keywords
Construction and Evaluation of a Novel Organic Anion Transporter 1/3 CRISPR/Cas9 Double-Knockout Rat Model
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14112307
Abstract: Background: Organic anion transporter 1 (OAT1) and OAT3 have an overlapping spectrum of substrates such that one can exert a compensatory effect when the other is dysfunctional. As a result, the knockout of either OAT1… read more here.
Keywords: knockout rat; rat model; knockout; double knockout ... See more keywords