An Asymmetric Synthesis of (+)-Isostrychnine Based on Catalytic Asymmetric Tandem Double Michael Addition.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c01828
Abstract: Herein, a concise asymmetric synthesis of (+)-isostrychnine is achieved in nine longest-linear steps with a 16% overall yield. The key features of this synthesis include the catalytic asymmetric tandem double Michael addition of a tryptamine-derived… read more here.
Keywords: tandem double; asymmetric tandem; synthesis isostrychnine; double michael ... See more keywords
Synthesis of 4-Imidazolidinones from Diamides and Ethynyl Benziodoxolones via Double Michael-Type Addition: Ethynyl Benziodoxolones as Electrophilic Ynol Synthons.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.26434/chemrxiv-2022-bb2bt
Abstract: The moiety of 4-imidazolidinone is an important structural motif in organic synthesis and medicinal chemistry. We present the synthesis of 4-imidazolidinones from various diamides with ethynyl benziodoxolones through double Michael-type addition, which is an unprecedented… read more here.
Keywords: diamides ethynyl; ethynyl benziodoxolones; type addition; double michael ... See more keywords