An Aβ42 double mutant inhibits Aβ42-induced plasma and mitochondrial membrane disruption in artificial membranes, isolated organs and intact cells.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00638
Abstract: Destabilization of plasma and inner mitochondrial membranes by extra- and intracellular amyloid β peptide (Aβ42) aggregates may lead to dysregulated calcium flux through the plasma membrane, mitochondrial-mediated apoptosis and neuronal cell death in patients with… read more here.
Keywords: membranes isolated; artificial membranes; plasma mitochondrial; mitochondrial membrane ... See more keywords
GCR1 and GPA1 coupling regulates nitrate, cell wall, immunity and light responses in Arabidopsis
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-42084-2
Abstract: G-protein signaling components have been attributed many biological roles in plants, but the extent of involvement of G-protein coupled receptor 1 (GCR1) with the Gα (GPA1) remained unknown. To address this, we have performed transcriptomic… read more here.
Keywords: gpa1; coupling regulates; gcr1 gpa1; gpa1 coupling ... See more keywords
Synergistic stabilization of a double mutant in chymotrypsin inhibitor 2 from a library screen in E. coli
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02490-7
Abstract: Most single point mutations destabilize folded proteins. Mutations that stabilize a protein typically only have a small effect and multiple mutations are often needed to substantially increase the stability. Multiple point mutations may act synergistically… read more here.
Keywords: synergistic stabilization; screen coli; stability; chymotrypsin inhibitor ... See more keywords
Structure-activity exploration of a small-molecule allosteric inhibitor of T790M/L858R double mutant EGFR
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2145284
Abstract: Abstract EGFR is a protein kinase whose aberrant activity is frequently involved in the development of non-small lung cancer (NSCLC) drug resistant forms. The allosteric inhibition of this enzyme is currently one among the most… read more here.
Keywords: structure activity; allosteric inhibitor; mutant egfr; egfr ... See more keywords
Elevated P21 (CDKN1a) Mediates Apoptosis of Beta-Thalassemic Erythroid Cells in Mice but Its Ablation Doesn't Improve Erythroid Maturation
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-143384
Abstract: Beta-thalassemias are caused by mutations in the β-globin gene leading to anemia. In β-thalassemia, excessive accumulation of unpaired α globin chains in erythroblasts, triggers redox-mediated reactions, which is associated with increased production of immature erythroid… read more here.
Keywords: beta thalassemic; mice; p21; maturation ... See more keywords
MAG2 and MAL Regulate Vesicle Trafficking and Auxin Homeostasis With Functional Redundancy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.849532
Abstract: Auxin is a central phytohormone and controls almost all aspects of plant development and stress response. Auxin homeostasis is coordinately regulated by biosynthesis, catabolism, transport, conjugation, and deposition. Endoplasmic reticulum (ER)-localized MAIGO2 (MAG2) complex mediates… read more here.
Keywords: vesicle trafficking; auxin homeostasis; mag2 mal; double mutant ... See more keywords
Frequency and Clinicopathological Characteristics of Patients With KRAS/BRAF Double-Mutant Colorectal Cancer: An In Silico Study
Sign Up to like & getrecommendations! Published in 2022 at "Pathology and Oncology Research"
DOI: 10.3389/pore.2022.1610206
Abstract: KRAS and BRAF mutations are currently thought to be mutually exclusive as their co-occurrence is extremely rare. Therefore, clinicopathological and molecular characteristics of colorectal carcinoma with KRAS/BRAF double mutations are unclear. We aimed to investigate… read more here.
Keywords: kras braf; mutant colorectal; braf double; colorectal carcinoma ... See more keywords
Sucrose Synthase and Fructokinase Are Required for Proper Meristematic and Vascular Development
Sign Up to like & getrecommendations! Published in 2022 at "Plants"
DOI: 10.3390/plants11081035
Abstract: Sucrose synthase (SuSy) and fructokinase (FRK) work together to control carbohydrate flux in sink tissues. SuSy cleaves sucrose into fructose and UDP-glucose; whereas FRK phosphorylates fructose. Previous results have shown that suppression of the SUS1,3&4… read more here.
Keywords: vascular development; development; sucrose synthase; double mutant ... See more keywords
Virtual screening and molecular dynamics simulation study of approved drugs as a binder to the linoleic acid binding site on spike protein of SARS-CoV-2 and double mutant (E484Q and L452R)
Sign Up to like & getrecommendations! Published in 2022 at "Indian Journal of Pharmacology"
DOI: 10.4103/ijp.ijp_111_22
Abstract: INTRODUCTION: Binding of linoleic acid (LA) to the spike trimer stabilizes it in closed conformation hindering its binding to angiotensin-converting enzyme-2, thus decreasing infectivity. In the current study, we tend to repurpose Food and Drug… read more here.
Keywords: virtual screening; approved drugs; sars cov; binding site ... See more keywords