Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.aaw9032
Abstract: Seeing double can be a good thing Many human breast cancers harbor activating mutations in PIK3CA, the gene coding for the catalytic subunit of phosphoinositide 3-kinase (PI3K). Clinical trials are underway to evaluate the efficacy… read more here.
Keywords: breast cancers; double pik3ca; pik3ca mutations; pi3k inhibitors ... See more keywords
Abstract P3-03-01: DoublePIK3CAmutations incisdrive oncogene addiction and enhance sensitivity to PI3K alpha inhibitors in breast cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs19-p3-03-01
Abstract: Activating mutations in PIK3CA, the gene coding for the catalytic subunit (p110α) of phosphoinositide-3-kinase (PI3K), are the most frequent oncogenic alterations in estrogen receptor-positive (ER+) breast cancer and are also prevalent in other tumor types.… read more here.
Keywords: pik3ca mutations; breast cancer; sensitivity; double pik3ca ... See more keywords