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Published in 2019 at "Science"
DOI: 10.1126/science.aaw9032
Abstract: Seeing double can be a good thing Many human breast cancers harbor activating mutations in PIK3CA, the gene coding for the catalytic subunit of phosphoinositide 3-kinase (PI3K). Clinical trials are underway to evaluate the efficacy…
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Keywords:
breast cancers;
double pik3ca;
pik3ca mutations;
pi3k inhibitors ... See more keywords
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Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs19-p3-03-01
Abstract: Activating mutations in PIK3CA, the gene coding for the catalytic subunit (p110α) of phosphoinositide-3-kinase (PI3K), are the most frequent oncogenic alterations in estrogen receptor-positive (ER+) breast cancer and are also prevalent in other tumor types.…
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Keywords:
pik3ca mutations;
breast cancer;
sensitivity;
double pik3ca ... See more keywords