Are Anaphase Events Really Irreversible? The Endmost Stages of Cell Division and the Paradox of the DNA Double‐Strand Break Repair
Sign Up to like & getrecommendations! Published in 2020 at "BioEssays"
DOI: 10.1002/bies.202000021
Abstract: It has been recently demonstrated that yeast cells are able to partially regress chromosome segregation in telophase as a response to DNA double‐strand breaks (DSBs), likely to find a donor sequence for homology‐directed repair (HDR).… read more here.
Keywords: double strand; anaphase events; dna double; repair ... See more keywords
Double‐strand breakage in the extrachromosomal double minutes triggers their aggregation in the nucleus, micronucleation, and morphological transformation
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DOI: 10.1002/gcc.22810
Abstract: Gene amplification plays a pivotal role in malignant transformation. Amplified genes often reside on extrachromosomal double minutes (DMs). Low‐dose hydroxyurea induces DM aggregation in the nucleus which, in turn, generates micronuclei composed of DMs. Low‐dose… read more here.
Keywords: strand breakage; double minutes; breakage; double strand ... See more keywords
The role of double‐strand break repair, translesion synthesis, and interstrand crosslinks in colorectal cancer progression—clinicopathological data and survival
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.25737
Abstract: DNA repair is a new and important pathway that explains colorectal carcinogenesis. This study will evaluate the prognostic value of molecular modulation of double‐strand break repair (XRCC2 and XRCC5); DNA damage tolerance/translesion synthesis (POLH, POLK,… read more here.
Keywords: break repair; colorectal cancer; translesion synthesis; strand break ... See more keywords
A double-strand-break model for the relative biological effectiveness of electrons based on ionization clustering.
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DOI: 10.1002/mp.15796
Abstract: BACKGROUND The effectiveness of ionizing radiation regarding DNA damage induction depends on its spatial energy deposition pattern. For electrons an increased effectiveness is observed at low kinetic energies due to the enhanced density of energy… read more here.
Keywords: biological effectiveness; model; double strand; relative biological ... See more keywords
DNA Double-Strand Break-Induced Gene Amplification in Yeast.
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DOI: 10.1007/978-1-0716-0644-5_17
Abstract: Precise control of the gene copy number in the model yeast Saccharomyces cerevisiae may facilitate elucidation of enzyme functions or, in cell factory design, can be used to optimize production of proteins and metabolites. Currently,… read more here.
Keywords: induced gene; dna double; strand break; double strand ... See more keywords
Sequencing Spo11 Oligonucleotides for Mapping Meiotic DNA Double-Strand Breaks in Yeast.
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DOI: 10.1007/978-1-4939-6340-9_3
Abstract: Meiosis is a specialized form of cell division resulting in reproductive cells with a reduced, usually haploid, genome complement. A key step after premeiotic DNA replication is the occurrence of homologous recombination at multiple places… read more here.
Keywords: dna; sequencing spo11; dna double; strand breaks ... See more keywords
Genes, Proteins, and Biological Pathways Preventing Chromothripsis.
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DOI: 10.1007/978-1-4939-7780-2_15
Abstract: The highly complex structural genome variations chromothripsis, chromoanasynthesis, and chromoplexy are subsumed under the term chromoanagenesis, which means chromosome rebirth. Precipitated by numerous DNA double-strand breaks, they differ in number of and distances between breakpoints,… read more here.
Keywords: biological pathways; chromothripsis; double strand; genes proteins ... See more keywords
Radiation-induced DNA double-strand breaks in peripheral leukocytes and therapeutic response of heel spur patients treated by orthovoltage X-rays or a linear accelerator
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DOI: 10.1007/s00066-020-01662-4
Abstract: Purpose Biodosimetric assessment and comparison of radiation-induced deoxyribonucleic acid (DNA) double-strand breaks (DSBs) by γH2AX immunostaining in peripheral leukocytes of patients with painful heel spur after radiation therapy (RT) with orthovoltage X‑rays or a 6-MV linear… read more here.
Keywords: response; radiation induced; orthovoltage rays; dna double ... See more keywords
RAP80, ubiquitin and SUMO in the DNA damage response
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DOI: 10.1007/s00109-017-1561-1
Abstract: A decade has passed since the first reported connection between RAP80 and BRCA1 in DNA double-strand break repair. Despite the initial identification of RAP80 as a factor localizing BRCA1 to DNA double-strand breaks and potentially… read more here.
Keywords: rap80; ubiquitin sumo; dna; dna double ... See more keywords
The meiotic-specific Mek1 kinase in budding yeast regulates interhomolog recombination and coordinates meiotic progression with double-strand break repair
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DOI: 10.1007/s00294-019-00937-3
Abstract: Recombination, along with sister chromatid cohesion, is used during meiosis to physically connect homologous chromosomes so that they can be segregated properly at the first meiotic division. Recombination is initiated by the introduction of programmed… read more here.
Keywords: kinase; double strand; recombination; activity ... See more keywords
Analyses of DNA double-strand break repair pathways in tandem arrays of HXT genes of Saccharomyces cerevisiae.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of microbiology"
DOI: 10.1007/s12275-020-0461-1
Abstract: Eukaryotic genomes contain numerous homologous repeat sequences including redundant genes with divergent homology that can be potential recombination targets. Recombination between divergent sequences is rare but poses a substantial threat to genome stability. The hexose… read more here.
Keywords: tandem arrays; dna double; hxt genes; double strand ... See more keywords