Early born neurons are abnormally positioned in the doublecortin knockout hippocampus
Sign Up to like & getrecommendations! Published in 2017 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddw370
Abstract: Human doublecortin (DCX) mutations are associated with severe brain malformations leading to aberrant neuron positioning (heterotopia), intellectual disability and epilepsy. The Dcx protein plays a key role in neuronal migration, and hippocampal pyramidal neurons in… read more here.
Keywords: early born; doublecortin; dcx; gene expression ... See more keywords
Doublecortin and JIP3 are neural-specific counteracting regulators of dynein-mediated retrograde trafficking
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DOI: 10.1101/2022.08.10.503449
Abstract: Mutations in the microtubule (MT)-binding protein doublecortin (DCX) or in the MT- based molecular motor dynein result in lissencephaly. However, a functional link between DCX and dynein has not been defined. Here, we demonstrate that… read more here.
Keywords: doublecortin; dcx; jip3; dynein mediated ... See more keywords