Ciliary Doublet Microtubules at Near-Atomic Resolution
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.10.013
Abstract: The beauty of the eukaryotic cilium has been appreciated since electron microscopy first revealed its 9-fold symmetry. In this issue of Cell, Ma et al. use cryoelectron microscopy and modeling to define doublet microtubules at near-atomic resolution,… read more here.
Keywords: microtubules near; microscopy; doublet microtubules; near atomic ... See more keywords
SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2207605119
Abstract: Significance Cilia are cell-surface organelles with cytoskeletons formed by different microtubule types. These microtubules are decorated inside and out by proteins that alter microtubule stability and elasticity and allow cilia to beat. Mutations in these… read more here.
Keywords: lumenal protein; singlet; human ciliary; spaca9 lumenal ... See more keywords
Native doublet microtubules from Tetrahymena thermophila reveal the importance of outer junction proteins
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DOI: 10.1101/2022.09.30.510376
Abstract: Using cryo-EM, the authors identified 42 MIPs, including outer junction protein CFAP77 and outer dense fibers, in native doublet microtubules of Tetrahymena thermophila . Knockout of CFAP77 reduced ciliary beat frequency and led to outer… read more here.
Keywords: junction; doublet microtubules; native doublet; outer junction ... See more keywords