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   Articles with "dovitinib" as a keyword



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A phase II trial of dovitinib in previously-treated advanced pleural mesothelioma: The Ontario Clinical Oncology Group.

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recommendations! Published in 2017 at "Lung cancer"

DOI: 10.1016/j.lungcan.2016.12.004

Abstract: OBJECTIVES Following failure of a platinum-antifolate combination regimen, there is no standard therapy for advanced malignant pleural mesothelioma (MPM). The fibroblast growth factor receptor (FGFR) signaling pathways may be a relevant target in MPM. Dovitinib… read more here.

Keywords: dovitinib; pleural mesothelioma; previously treated; oncology ... See more keywords
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In Vitro Effect of Dovitinib (TKI258), a Multi-Target Angiokinase Inhibitor on Aggressive Meningioma Cells

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recommendations! Published in 2020 at "Cancer Investigation"

DOI: 10.1080/07357907.2020.1773844

Abstract: Abstract Background: Meningiomas represent ∼30% of primary central nervous system (CNS) tumors. Although advances in surgery and radiotherapy have significantly improved survival, there remains an important subset of patients whose tumors have more aggressive behavior… read more here.

Keywords: multi; dovitinib; inhibitor; vitro effect ... See more keywords

Co-clinical trials demonstrate predictive biomarkers for dovitinib, an FGFR inhibitor, in lung squamous cell carcinoma

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recommendations! Published in 2017 at "Annals of Oncology"

DOI: 10.1093/annonc/mdx098

Abstract: Background We conducted co-clinical trials in patient-derived xenograft (PDX) models to identify predictive biomarkers for the multikinase inhibitor dovitinib in lung squamous cell carcinoma (LSCC). Methods The PDX01-02 were established from LSCC patients enrolled in… read more here.

Keywords: dovitinib; clinical trials; pdx; gene ... See more keywords

A Phase II Study of Dovitinib in Patients with Recurrent or Metastatic Adenoid Cystic Carcinoma

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recommendations! Published in 2017 at "Clinical Cancer Research"

DOI: 10.1158/1078-0432.ccr-16-2942

Abstract: Purpose: Genetic and preclinical studies have implicated FGFR signaling in the pathogenesis of adenoid cystic carcinoma (ACC). Dovitinib, a suppressor of FGFR activity, may be active in ACC. Experimental Design: In a two-stage phase II… read more here.

Keywords: dovitinib; response; cystic carcinoma; phase study ... See more keywords
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A mutation-specific, single-arm, phase 2 study of dovitinib in patients with advanced malignancies

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recommendations! Published in 2020 at "Oncotarget"

DOI: 10.18632/oncotarget.27530

Abstract: Background: Receptor tyrosine kinases (RTKs) play key roles in tumorigenesis. The multi-RTK inhibitor dovitinib has demonstrated promising antitumor activity in multiple cancers. Patients and Methods: In this phase 2, open-label, single-arm study, patients with advanced… read more here.

Keywords: advanced malignancies; dovitinib; study; single arm ... See more keywords