Downregulation of adipose triglyceride lipase by EB viral‐encoded LMP2A links lipid accumulation to increased migration in nasopharyngeal carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12824
Abstract: Epstein–Barr virus (EBV)‐associated nasopharyngeal carcinoma (NPC) is one of the most common human cancers in South‐East Asia exhibiting typical features of lipid accumulation. EBV‐encoded latent membrane protein 2A (LMP2A) is expressed in most NPCs enhancing… read more here.
Keywords: accumulation; lipid accumulation; migration; downregulation ... See more keywords
Downregulation of tripartite motif protein 11 attenuates cardiomyocyte apoptosis after ischemia/reperfusion injury via DUSP1-JNK1/2.
Sign Up to like & getrecommendations! Published in 2021 at "Cell biology international"
DOI: 10.1002/cbin.11716
Abstract: BACKGROUND Currently, the prevention of ischemic diseases such as myocardial infarction associated with ischemia/reperfusion (I/R) injury remains to be a challenge. Thus, this study was designed to explore the effects of tripartite motif protein 11… read more here.
Keywords: overexpression; trim11; apoptosis; dusp1 ... See more keywords
Improving strategies in the development of protein-downregulation based antiandrogens.
Sign Up to like & getrecommendations! Published in 2021 at "ChemMedChem"
DOI: 10.1002/cmdc.202100033
Abstract: AR plays a crucial role in the occurrence and development of prostate cancer (PCa) and its signaling pathway remains active in castration-resistant prostate cancer (CRPC) patients. The drug resistance of current clinical used antiandrogens is… read more here.
Keywords: protein; improving strategies; strategies development; downregulation ... See more keywords
HPV16 E6 promotes cervical cancer cell migration and invasion by downregulation of NHERF1
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.31876
Abstract: HPV16 is the predominant type of HPV causing invasive cervical cancer. However, the underlying molecular mechanism of the unparalleled carcinogenic power of HPV16 compared to other types of high‐risk (HR)‐HPV including HPV18 remains elusive. The… read more here.
Keywords: cervical cancer; hpv16; downregulation; cancer ... See more keywords
DNMT3a‐triggered downregulation of K2p1.1 gene in primary sensory neurons contributes to paclitaxel‐induced neuropathic pain
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32155
Abstract: Antineoplastic drugs induce dramatic transcriptional changes in dorsal root ganglion (DRG) neurons, which may contribute to chemotherapy‐induced neuropathic pain. K2p1.1 controls neuronal excitability by setting the resting membrane potential. Here, we report that systemic injection… read more here.
Keywords: k2p1; paclitaxel induced; dnmt3a; drg ... See more keywords
Consequences of HLA‐associated mutations in HIV‐1 subtype C Nef on HLA‐I downregulation ability
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DOI: 10.1002/jmv.25676
Abstract: Identification of CD8+ T lymphocyte (CTL) escape mutations that compromise the pathogenic functions of the Nef protein may be relevant for an HIV‐1 attenuation‐based vaccine. Previously, HLA‐associated mutations 102H, 105R, 108D, and 199Y were individually… read more here.
Keywords: hla downregulation; downregulation ability; downregulation; nef ... See more keywords
Downregulation of tyrosine hydroxylase phenotype after AAV injection above substantia nigra: Caution in experimental models of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24363
Abstract: Adeno‐associated virus (AAV) vector‐mediated delivery of human α‐synuclein (α‐syn) gene in rat substantia nigra (SN) results in increased expression of α‐syn protein in the SN and striatum which can progressively degenerate dopaminergic neurons. Therefore, this… read more here.
Keywords: aav; substantia nigra; expression; downregulation ... See more keywords
CDX2 downregulation in mouse mural trophectoderm during peri‐implantation is heteronomous, dependent on the YAP‐TEAD pathway and controlled by estrogen‐induced factors
Sign Up to like & getrecommendations! Published in 2022 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12446
Abstract: Abstract Purpose To investigate the transition of CDX2 expression patterns in mouse trophectoderm (TE) and its regulatory mechanisms during implantation. Methods Mouse E3.5–4.5 blastocysts were used to immunostain CDX2, YAP, TEAD4, and ESRRB. Endogenous estrogen… read more here.
Keywords: cdx2 downregulation; yap tead; cdx2 expression; estrogen ... See more keywords
Alteration of the translational readthrough isoform AQP4ex induces redistribution and downregulation of AQP4 in human glioblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-04123-y
Abstract: Glioblastoma multiforme (GBM) is characterized by a remarkable cellular and molecular heterogeneity that make the behavior of this tumor highly variable and resistant to therapy. In addition, the most serious clinical complication of GBM and… read more here.
Keywords: readthrough isoform; aqp4ex; glioblastoma; gbm ... See more keywords
Interferon gamma decreases intestinal epithelial aquaporin 3 expression through downregulation of constitutive transcription
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-018-1681-2
Abstract: Aquaporin (AQP) 3 expression is altered in inflammatory bowel diseases, although the exact mechanisms regulating AQP abundance are unclear. Although interferon gamma (IFNγ) is centrally involved in intestinal inflammation, the effect of this cytokine on… read more here.
Keywords: ifn; constitutive transcription; aqp3; expression ... See more keywords
The clinical significance of miR-335, miR-124, miR-218 and miR-484 downregulation in gastric cancer
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biology Reports"
DOI: 10.1007/s11033-018-4278-5
Abstract: Gastric cancer (GC) is one of the leading types of malignancy worldwide, particularly in Asian populations. Although the exact molecular mechanism of GC development remains unknown, microRNA (miRNA) has recently been shown to be involved.… read more here.
Keywords: mir 218; mir; 124 mir; downregulation ... See more keywords