Modulation of Extreme Flood Levels by Impoundment Significantly Offset by Floodplain Loss Downstream of the Three Gorges Dam
Sign Up to like & getrecommendations! Published in 2018 at "Geophysical Research Letters"
DOI: 10.1002/2017gl076935
Abstract: River flooding—the world’s most significant natural hazard—is likely to increase under anthropogenic climate change. Most large rivers have been regulated by damming, but the extent to which these impoundments can mitigate extreme flooding remains uncertain.… read more here.
Keywords: hydrology; gorges dam; three gorges; extreme flood ... See more keywords
High-throughput downstream process development for cell-based products using aqueous two-phase systems (ATPS) - A case study.
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology journal"
DOI: 10.1002/biot.201600587
Abstract: The availability of preparative-scale downstream processing strategies for cell-based products presents a critical juncture between fundamental research and clinical development. Aqueous two-phase systems (ATPS) present a gentle, scalable, label-free, and cost-effective method for cell purification,… read more here.
Keywords: phase; cell based; downstream; cell ... See more keywords
Strategies to control therapeutic antibody glycosylation during bioprocessing: Synthesis and separation
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28066
Abstract: Glycosylation can be a critical quality attribute in biologic manufacturing. In particular, it has implications on the half‐life, immunogenicity, and pharmacokinetics of therapeutic monoclonal antibodies (mAbs), and must be closely monitored throughout drug development and… read more here.
Keywords: therapeutic antibody; antibody glycosylation; glycosylation; downstream ... See more keywords
Process economics evaluation and optimization of adeno-associated virus downstream processing.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28402
Abstract: Adeno-associated virus (AAV) manufacturing has traditionally focused upon lab-scale techniques to culture and purify vector products, leading to limitations in production capacity. The tool presented in this paper assesses the feasibility of using non-scalable technologies… read more here.
Keywords: economics; process economics; associated virus; adeno associated ... See more keywords
Cationic polymer precipitation for enhanced impurity removal in downstream processing.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28416
Abstract: Precipitation can be used for the removal of impurities early in the downstream purification process of biologics, with the soluble product remaining in the filtrate through microfiltration. The objective of this study was to examine… read more here.
Keywords: purification; paa; removal; cationic polymer ... See more keywords
Advances in high-throughput, high-capacity nonwoven membranes for chromatography in downstream processing: A review.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28457
Abstract: Nonwoven membranes are highly engineered fibrous materials that can be manufactured on a large scale from a wide range of different polymers, and their surfaces can be modified using a large variety of different chemistries… read more here.
Keywords: chromatography downstream; nonwoven membranes; high throughput; downstream processing ... See more keywords
Reviewing the process intensification landscape through the introduction of a novel, multitiered classification for downstream processing
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28641
Abstract: A demand for process intensification in biomanufacturing has increased over the past decade due to the ever‐expanding market for biopharmaceuticals. This is largely driven by factors such as a surge in biosimilars as patents expire,… read more here.
Keywords: process intensification; intensification; downstream; reviewing process ... See more keywords
Downstream Process Intensification for AAV Purification by Affinity Chromatography Using Single Pass Tangential Flow Filtration.
Sign Up to like & getrecommendations! Published in 2025 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.70090
Abstract: To enable adeno‐associated viral vectors (AAV) to achieve their maximum potential, next‐generation manufacturing processes must be developed to make gene therapies more affordable and accessible. This study focused on the design of two different intensified… read more here.
Keywords: process; affinity; downstream; scale ... See more keywords
Pool‐less processing to streamline downstream purification of monoclonal antibodies
Sign Up to like & getrecommendations! Published in 2017 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.201600104
Abstract: With cell culture titers and productivity increasing in the last few years, pressure has been placed on downstream purification to look at alternative strategies to meet the demand of biotech products with high dose requirements.… read more here.
Keywords: pool less; purification; process; downstream ... See more keywords
Impounded sediment and dam removal: Erosion rates and proximal downstream fate
Sign Up to like & getrecommendations! Published in 2024 at "Earth Surface Processes and Landforms"
DOI: 10.1002/esp.5850
Abstract: Sediment management is an important aspect of dam removal projects, often driving costs and influencing community acceptance. For dams storing uncontaminated sediments, downstream release is often the cheapest and most practical approach and can be… read more here.
Keywords: dam; dam removal; downstream; erosion ... See more keywords
Increased Mercury and Reduced Insect Diversity in Linked Stream-Riparian Food Webs Downstream of a Historical Mercury Mine.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.5342
Abstract: Historical mining left a legacy of abandoned mines and waste rock in remote headwaters of major river systems in the western United States. Understanding the influence of these legacy mines on culturally and ecological important… read more here.
Keywords: increased mercury; food webs; insects; mining ... See more keywords