Converting a mAb downstream process from batch to continuous using process modeling and process analytical technology
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DOI: 10.1002/biot.202100351
Abstract: The biopharmaceutical market is driving the revolution from traditional batch processes to continuous manufacturing for higher productivity and lower costs. In this work, a batch mAb downstream process has been converted into an integrated continuous… read more here.
Keywords: mab downstream; downstream process; batch; process ... See more keywords
An integrated and continuous downstream process for microbial virus‐like particle vaccine biomanufacture
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DOI: 10.1002/bit.28118
Abstract: In this study, we present the first integrated and continuous downstream process for the production of microbial virus‐like particle vaccines. Modular murine polyomavirus major capsid VP1 with integrated J8 antigen was used as a model… read more here.
Keywords: continuous downstream; process; downstream process; integrated continuous ... See more keywords
Mass spectrometric evaluation of upstream and downstream process influences on host cell protein patterns in biopharmaceutical products
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DOI: 10.1002/btpr.2788
Abstract: For production of different monoclonal antibodies (mAbs), biopharmaceutical companies often use related upstream and downstream manufacturing processes. Such platforms are typically characterized regarding influence of upstream and downstream process (DSP) parameters on critical quality attributes… read more here.
Keywords: upstream downstream; hcp; process; biopharmaceutical products ... See more keywords
Comprehensive studies on building a scalable downstream process for mRNAs to enable mRNA therapeutics
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DOI: 10.1002/btpr.3301
Abstract: In recent years, mRNA‐based therapeutics have been a fast‐growing new class of biologics that can, in principle, encode any protein(s) directly in patients to treat various diseases. mRNA vaccines have been proven to work efficiently,… read more here.
Keywords: studies building; scalable downstream; downstream process; comprehensive studies ... See more keywords