Strain evolution and novel downstream processing with integrated catalysis enable highly efficient co-production of 1,3-Propanediol and organic acid esters from crude glycerol.
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28070
Abstract: Bioconversion of natural microorganisms generally results in a mixture of various compounds. Downstream processing (DSP) which only targets a single product often lacks economic competitiveness due to incomplete use of raw material and high cost… read more here.
Keywords: downstream processing; crude glycerol; production propanediol; glycerol ... See more keywords
Process economics evaluation and optimization of adeno-associated virus downstream processing.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28402
Abstract: Adeno-associated virus (AAV) manufacturing has traditionally focused upon lab-scale techniques to culture and purify vector products, leading to limitations in production capacity. The tool presented in this paper assesses the feasibility of using non-scalable technologies… read more here.
Keywords: economics; process economics; associated virus; adeno associated ... See more keywords
Advances in high-throughput, high-capacity nonwoven membranes for chromatography in downstream processing: A review.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28457
Abstract: Nonwoven membranes are highly engineered fibrous materials that can be manufactured on a large scale from a wide range of different polymers, and their surfaces can be modified using a large variety of different chemistries… read more here.
Keywords: chromatography downstream; nonwoven membranes; high throughput; downstream processing ... See more keywords
Downstream processing of serinol from a glycerol‐based fermentation broth and transfer to other amine containing molecules
Sign Up to like & getrecommendations! Published in 2017 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.201600116
Abstract: A possible application of glycerol, which is produced in large amounts as a by‐product from the biodiesel industry, is its fermentation to serinol (2‐amino‐1,3‐propanediol), a glycerol derivative. The downstream processing of this glycerol‐based fermentation broth… read more here.
Keywords: amino; downstream processing; glycerol; serinol ... See more keywords
Electrofiltration improves dead‐end filtration of hyaluronic acid and presents an alternative downstream processing step that overcomes technological challenges of conventional methods
Sign Up to like & getrecommendations! Published in 2017 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.201600236
Abstract: Hyaluronic acid (HA) dispersion obtained from the bacteria Streptococcus equi was concentrated by electrofiltration. In the conventional downstream processing of HA, extraction and precipitation lead to increase in environmental issues, structural changes, and time and… read more here.
Keywords: filtration; downstream processing; hyaluronic acid; electrofiltration ... See more keywords
A critical review of recent trends, and a future perspective of optical spectroscopy as PAT in biopharmaceutical downstream processing
Sign Up to like & getrecommendations! Published in 2020 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-020-02407-z
Abstract: As competition in the biopharmaceutical market gets keener due to the market entry of biosimilars, process analytical technologies (PATs) play an important role for process automation and cost reduction. This article will give a general… read more here.
Keywords: pat; downstream processing; spectroscopy; critical review ... See more keywords
Production of gellan gum using milk skin residue (MSR)—a tea shop waste: statistical optimization and downstream processing
Sign Up to like & getrecommendations! Published in 2020 at "Biomass Conversion and Biorefinery"
DOI: 10.1007/s13399-020-01026-z
Abstract: In this work, the production and downstream processing of gellan gum obtained from milk skin residue (MSR) as a carbon source was investigated. The different medium variables, namely shaking speed, inoculum size, and nitrogen source,… read more here.
Keywords: gellan gum; msr; downstream processing; gellan ... See more keywords
Emerging biomaterials for downstream manufacturing of therapeutic proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2019.03.015
Abstract: Downstream processing is considered one of the most challenging phases of industrial manufacturing of therapeutic proteins, accounting for a large portion of the total production costs. The growing demand for therapeutic proteins in the biopharmaceutical… read more here.
Keywords: biomaterials downstream; therapeutic proteins; downstream processing; manufacturing therapeutic ... See more keywords
Producing fucoxanthin from algae - Recent advances in cultivation strategies and downstream processing.
Sign Up to like & getrecommendations! Published in 2021 at "Bioresource technology"
DOI: 10.1016/j.biortech.2021.126170
Abstract: Fucoxanthin, a brown-colored pigment from algae, is gaining much attention from industries and researchers recently due to its numerous potential health benefits, including anti-oxidant, anti-cancer, anti-obesity functions, and so on. Although current commercial production is… read more here.
Keywords: producing fucoxanthin; downstream processing; cultivation; recent advances ... See more keywords
Downstream processing technologies in the biocatalytic production of oligosaccharides.
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology advances"
DOI: 10.1016/j.biotechadv.2020.107568
Abstract: Oligosaccharides are important ingredients for food and feed products. There has therefore been much interest in the development of biocatalytic processes for their production. Irrespective of the oligosaccharide manufacturing route, that is, bottom-up synthesis or… read more here.
Keywords: production; production oligosaccharides; downstream processing; unit operations ... See more keywords
Electrospun amorphous solid dispersions of meloxicam: influence of polymer type and downstream processing to orodispersible dosage forms.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.118593
Abstract: The objectives of this work were to develop meloxicam based amorphous solid dispersion through electrospinning technique and evaluate the effect of the polymeric matrix on the physicochemical properties of the fibers and the downstream processing… read more here.
Keywords: downstream processing; solid dispersions; amorphous solid; dosage forms ... See more keywords