Ephrin (Eph) receptor and downstream signaling pathways: a promising potential targeted therapy for COVID‑19 and associated cancers and diseases
Sign Up to like & getrecommendations! Published in 2022 at "Human Cell"
DOI: 10.1007/s13577-022-00697-2
Abstract: Currently, the coronavirus disease 2019 (COVID-19) pandemic has become a serious concern to the worldwide healthcare system. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for COVID-19 and the emergence of new SARS-CoV-2 variants such… read more here.
Keywords: ephrin; receptor; eph receptor; downstream signaling ... See more keywords
Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.02.026
Abstract: Cytokines are classically thought to stimulate downstream signaling pathways through monotonic activation of receptors. We describe a severe anemia resulting from a homozygous mutation (R150Q) in the cytokine erythropoietin (EPO). Surprisingly, the EPO R150Q mutant… read more here.
Keywords: cytokine; functional selectivity; epo; selectivity cytokine ... See more keywords
The Double Roles of the Prostaglandin E2 EP2 Receptor in Intracerebral Hemorrhage.
Sign Up to like & getrecommendations! Published in 2017 at "Current drug targets"
DOI: 10.2174/1389450117666151209122826
Abstract: BACKGROUND Intracerebral hemorrhage (ICH), a subtype of stroke, brings high morbidity and mortality to human beings. Multiple studies indicated that neuroinflammation, excitotoxicity, oxidative stress, cytotoxicity resulted from the degradation products of blood clot play vital… read more here.
Keywords: intracerebral hemorrhage; signaling pathway; ep2 receptor; receptor ... See more keywords
Different Aberrant Changes of mGluR5 and Its Downstream Signaling Pathways in the Scrapie-Infected Cell Line and the Brains of Scrapie-Infected Experimental Rodents
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.844378
Abstract: Metabotropic glutamate receptor subtype 5 (mGluR5) is a G-protein-coupled receptor found widely in the central nervous system. It has been involved in the development and progression of some neurodegenerative diseases, but its role in prion… read more here.
Keywords: prion; mglur5 downstream; downstream signaling; scrapie infected ... See more keywords
Antiplatelet Activity of Tussilagone via Inhibition of the GPVI Downstream Signaling Pathway in Platelets
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2020.00380
Abstract: Tussilagone is a sesquiterpenoid extracted from Tussilago farfara and is used as an oriental medicine for asthma and bronchitis. Although previous studies have shown that tussilagone has an inhibitory effect on platelet aggregation, no studies… read more here.
Keywords: medicine; gpvi downstream; tussilagone; downstream signaling ... See more keywords
Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in physiology"
DOI: 10.3389/fphys.2017.00048
Abstract: [This corrects the article on p. 48 in vol. 8, PMID: 28220078.]. read more here.
Keywords: activation downstream; signaling erk1; vegfr2 activation; inhibition vegfr2 ... See more keywords
Glycosaminoglycan-Mediated Downstream Signaling of CXCL8 Binding to Endothelial Cells
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DOI: 10.3390/ijms18122605
Abstract: The recruitment of leukocytes, mediated by endothelium bound chemokine gradients, is a vital process in inflammation. The highly negatively charged, unbranched polysaccharide family of glycosaminoglycans (GAGs), such as heparan sulfate and chondroitin sulfate mediate chemokine… read more here.
Keywords: endothelial downstream; cxcl8; endothelial cells; glycosaminoglycan mediated ... See more keywords
C-terminus of OX2R significantly affects downstream signaling pathways
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2017.6557
Abstract: The human orexin 2 receptor (OX2R) is a G-protein-coupled receptor (GPCR) that has been implicated in a number of diverse physiological functions. Recent studies have identified a number of functions of the C-termini of GPCRs.… read more here.
Keywords: downstream signaling; 385 414; terminus ox2r; significantly affects ... See more keywords
N6-methyladenosine regulates ATM expression and downstream signaling
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DOI: 10.7150/jca.64061
Abstract: N6-methyladenosine (m6A) is the most abundant modification in eukaryotic mRNAs, which plays an important role in regulating multiple biological processes. ATM is a major protein kinase that regulates the DNA damage response. Here, we identified… read more here.
Keywords: methyladenosine; atm expression; expression downstream; expression ... See more keywords