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Published in 2022 at "Human Cell"
DOI: 10.1007/s13577-022-00697-2
Abstract: Currently, the coronavirus disease 2019 (COVID-19) pandemic has become a serious concern to the worldwide healthcare system. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for COVID-19 and the emergence of new SARS-CoV-2 variants such…
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Keywords:
ephrin;
receptor;
eph receptor;
downstream signaling ... See more keywords
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Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.02.026
Abstract: Cytokines are classically thought to stimulate downstream signaling pathways through monotonic activation of receptors. We describe a severe anemia resulting from a homozygous mutation (R150Q) in the cytokine erythropoietin (EPO). Surprisingly, the EPO R150Q mutant…
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Keywords:
cytokine;
functional selectivity;
epo;
selectivity cytokine ... See more keywords
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Published in 2017 at "Current drug targets"
DOI: 10.2174/1389450117666151209122826
Abstract: BACKGROUND Intracerebral hemorrhage (ICH), a subtype of stroke, brings high morbidity and mortality to human beings. Multiple studies indicated that neuroinflammation, excitotoxicity, oxidative stress, cytotoxicity resulted from the degradation products of blood clot play vital…
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Keywords:
intracerebral hemorrhage;
signaling pathway;
ep2 receptor;
receptor ... See more keywords
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2
Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.844378
Abstract: Metabotropic glutamate receptor subtype 5 (mGluR5) is a G-protein-coupled receptor found widely in the central nervous system. It has been involved in the development and progression of some neurodegenerative diseases, but its role in prion…
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Keywords:
prion;
mglur5 downstream;
downstream signaling;
scrapie infected ... See more keywords
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Published in 2020 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2020.00380
Abstract: Tussilagone is a sesquiterpenoid extracted from Tussilago farfara and is used as an oriental medicine for asthma and bronchitis. Although previous studies have shown that tussilagone has an inhibitory effect on platelet aggregation, no studies…
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Keywords:
medicine;
gpvi downstream;
tussilagone;
downstream signaling ... See more keywords
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Published in 2017 at "Frontiers in physiology"
DOI: 10.3389/fphys.2017.00048
Abstract: [This corrects the article on p. 48 in vol. 8, PMID: 28220078.].
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Keywords:
activation downstream;
signaling erk1;
vegfr2 activation;
inhibition vegfr2 ... See more keywords
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Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18122605
Abstract: The recruitment of leukocytes, mediated by endothelium bound chemokine gradients, is a vital process in inflammation. The highly negatively charged, unbranched polysaccharide family of glycosaminoglycans (GAGs), such as heparan sulfate and chondroitin sulfate mediate chemokine…
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Keywords:
endothelial downstream;
cxcl8;
endothelial cells;
glycosaminoglycan mediated ... See more keywords
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Published in 2017 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2017.6557
Abstract: The human orexin 2 receptor (OX2R) is a G-protein-coupled receptor (GPCR) that has been implicated in a number of diverse physiological functions. Recent studies have identified a number of functions of the C-termini of GPCRs.…
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Keywords:
downstream signaling;
385 414;
terminus ox2r;
significantly affects ... See more keywords
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Published in 2021 at "Journal of Cancer"
DOI: 10.7150/jca.64061
Abstract: N6-methyladenosine (m6A) is the most abundant modification in eukaryotic mRNAs, which plays an important role in regulating multiple biological processes. ATM is a major protein kinase that regulates the DNA damage response. Here, we identified…
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Keywords:
methyladenosine;
atm expression;
expression downstream;
expression ... See more keywords