MicroRNA-137 and its downstream target LSD1 inversely regulate anesthetics-induced neurotoxicity in dorsal root ganglion neurons
Sign Up to like & getrecommendations! Published in 2017 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2017.09.004
Abstract: PURPOSE Anesthetic reagents, such as bupivacaine (Bv), induce significant neurotoxicity in dorsal root ganglion neurons (DRGNs). In this study, we investigated the expression, function and cross-association of microRNA-137-3p (miR-137-3p) and lysine (K)-specific demethylase 1A (LSD1)… read more here.
Keywords: downstream target; mir 137; target lsd1; 137 downstream ... See more keywords
The ISR downstream target ATF4 represses long-term memory in a cell type–specific manner
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2407472121
Abstract: Significance The activation of the integrated stress response (ISR) underlies memory deficits in various cognitive disorders, but how ISR regulates long-term memory (LTM) remains largely unknown. Here, we show that deleting activating transcription factor 4… read more here.
Keywords: term memory; long term; downstream target;
A Role for Translational Regulation by S6 Kinase and a Downstream Target in Inflammatory Pain.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of pharmacology"
DOI: 10.1111/bph.15646
Abstract: BACKGROUND AND PURPOSE Translational controls pervade neurobiology. Nociceptors play an integral role in the detection and propagation of pain signals. Nociceptors can undergo persistent changes in their intrinsic excitability. Pharmacologic disruption of nascent protein synthesis… read more here.
Keywords: downstream target; kinase; role; pain ... See more keywords
p21Waf1/Cip1 Is a Novel Downstream Target of 40S Ribosomal S6 Kinase 2
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DOI: 10.3390/cancers16223783
Abstract: Simple Summary The majority of breast cancers express estrogen receptors (ER) and are treated with antiestrogens. However, many patients relapse and do not respond to further treatment. Therefore, an understanding of which molecules/pathways are affected… read more here.
Keywords: downstream target; novel downstream; breast; ribosomal kinase ... See more keywords
SENP5 acts as a downstream target of androgen receptor and contributes to prostate cancer growth
Sign Up to like & getrecommendations! Published in 2025 at "Oncology Letters"
DOI: 10.3892/ol.2025.15404
Abstract: The androgen receptor (AR) signaling pathway plays an important role in prostate cancer (PCa) progression. In the present study, a significant co-expression was found between SENPs and AR. In addition, SENP5 was obviously negatively correlated… read more here.
Keywords: downstream target; prostate cancer; androgen receptor; acts downstream ... See more keywords