Redox-Responsive and Drug-Embedded Silica Nanoparticles with Unique Self-Destruction Features for Efficient Gene/Drug Codelivery
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201606229
Abstract: The development of advanced gene/drug codelivery carriers with stimuli-responsive release manner for complementary cancer therapy is desirable. In this study, novel disulfide-bridged and doxorubicin (DOX)-embedded degradable silica nanoparticles (DS-DOX) with unique self-destruction features are synthesized… read more here.
Keywords: destruction; gene drug; drug; codelivery ... See more keywords
Multifunctional Molecular Beacon Micelles for Intracellular mRNA Imaging and Synergistic Therapy in Multidrug-Resistant Cancer Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Advanced functional materials"
DOI: 10.1002/adfm.201701027
Abstract: Multidrug resistance (MDR) resulting from overexpression of P-glycoprotein (Pgp) transporters increases the drug efflux and thereby limits the chemotherapeutic efficacy. It is desirable to administer both an MDR1 gene silencer and a chemotherapeutic agent in… read more here.
Keywords: multidrug; molecular beacon; dox; multidrug resistant ... See more keywords
Targeted Heating of Mitochondria Greatly Augments Nanoparticle-Mediated Cancer Chemotherapy.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202000181
Abstract: Cancer is the second leading cause of mortality globally. Various nanoparticles have been developed to improve the efficacy and safety of chemotherapy, photothermal therapy, and their combination for treating cancer. However, most of the existing… read more here.
Keywords: chemotherapy; heating mitochondria; nanoparticle; dox ... See more keywords
Porous silicon nanocarriers with stimulus-cleavable linkers for effective cancer therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202200076
Abstract: Porous silicon nanoparticles (pSiNPs) have been widely utilized as drug carriers due to their excellent biocompatibility, large surface area and versatile surface chemistry. However, the dispersion in pore size and biodegradability of pSiNPs arguably have… read more here.
Keywords: cleavable linkers; drug; stimulus cleavable; dox ... See more keywords
Boosting Doxorubicin‐Induced Mitochondria Apoptosis for the Monodrug‐Mediated Combination of Chemotherapy and Chemodynamic Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202045
Abstract: Doxorubicin (Dox)‐mediated generation of reactive oxygen radicals (ROS) for mitochondrial apoptosis is identified as a new cytotoxic mechanism in addition to the well‐established one via nuclear DNA replication interference. However, this mechanism contributes far less… read more here.
Keywords: apoptosis; dox; combination; doxorubicin ... See more keywords
A Novel Tri‐Functional Liposome Re‐Educates “Cold Tumor” and Abrogates Tumor Growth by Synergizing Autophagy Inhibition and PD‐L1 Blockade
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202757
Abstract: Immunotherapy has been regarded as a breakthrough in cancer treatment and achieved great success. However, the poor response rate is still a formidable challenge of current immunotherapies, especially in solid tumors without sufficient infiltration of… read more here.
Keywords: tumor growth; cold tumor; dox; novel tri ... See more keywords
Self‐Stabilized Hyaluronate Nanogel for Intracellular Codelivery of Doxorubicin and Cisplatin to Osteosarcoma
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DOI: 10.1002/advs.201700821
Abstract: Abstract Osteosarcoma is one of the most serious bone malignancies with rapid speed of deterioration and low survival rate in children and teenagers. Chemotherapy is an important treatment for osteosarcoma, while the conventional small‐molecule therapeutics… read more here.
Keywords: cisplatin; osteosarcoma; self stabilized; cddp ... See more keywords
MT1‐MMP‐Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy
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DOI: 10.1002/advs.201902746
Abstract: Abstract Promoting tumor angiogenesis effectively and specifically to resolve tumor‐associated hypoperfusion holds promise for improving pancreatic cancer therapy. Herein, a doxorubicin (DOX) loaded smart liposome, MC‐T‐DOX, is constructed, that carries appropriately low‐density cilengitide, an αvβ3… read more here.
Keywords: mt1 mmp; pancreatic cancer; dox; therapy ... See more keywords
Preparation of a pH‐responsive chitosan‐montmorillonite‐nitrogen‐doped carbon quantum dots nanocarrier for attenuating doxorubicin limitations in cancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.202200016
Abstract: Despite its widespread usage as a chemotherapy drug in cancer treatment, doxorubicin (DOX) has limitations such as short in vivo circulation time, low solubility, and poor permeability. In this regard, a pH‐responsive chitosan (CS)‐ montmorillonite… read more here.
Keywords: chitosan montmorillonite; responsive chitosan; nitrogen doped; dox ... See more keywords
Trehalose alleviates doxorubicin‐induced cardiotoxicity in female Swiss albino mice by suppression of oxidative stress and autophagy
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22859
Abstract: Clinically, the use of doxorubicin (DOX) is limited due to DOX‐induced cardiotoxicity (DIC). The current study aimed to evaluate the cardioprotective effect of trehalose (TRE) against DIC in a female Swiss albino mouse model. Mice… read more here.
Keywords: induced cardiotoxicity; group; dox; mice ... See more keywords
Effects of bone marrow‐derived mesenchymal stem cells on doxorubicin‐induced liver injury in rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22985
Abstract: Doxorubicin (DOX) is a potent chemotherapeutic agent and has toxic effects on various organs, including the liver. In the current study, we aimed to investigate the effects of bone‐marrow‐derived mesenchymal stem cell (BM‐MSC) administration on… read more here.
Keywords: administration; bone marrow; dox; liver injury ... See more keywords