Redox-Responsive and Drug-Embedded Silica Nanoparticles with Unique Self-Destruction Features for Efficient Gene/Drug Codelivery
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DOI: 10.1002/adfm.201606229
Abstract: The development of advanced gene/drug codelivery carriers with stimuli-responsive release manner for complementary cancer therapy is desirable. In this study, novel disulfide-bridged and doxorubicin (DOX)-embedded degradable silica nanoparticles (DS-DOX) with unique self-destruction features are synthesized… read more here.
Keywords: destruction; gene drug; drug; codelivery ... See more keywords
Multifunctional Molecular Beacon Micelles for Intracellular mRNA Imaging and Synergistic Therapy in Multidrug-Resistant Cancer Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Advanced functional materials"
DOI: 10.1002/adfm.201701027
Abstract: Multidrug resistance (MDR) resulting from overexpression of P-glycoprotein (Pgp) transporters increases the drug efflux and thereby limits the chemotherapeutic efficacy. It is desirable to administer both an MDR1 gene silencer and a chemotherapeutic agent in… read more here.
Keywords: multidrug; molecular beacon; dox; multidrug resistant ... See more keywords
Zn/Cu Bi‐Single‐Atom Nanoplatform: Hexagonal Anti‐Tumor Warrior by ROS Amplification for DOX Resistance Reversal and Immune Activation
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DOI: 10.1002/adfm.202410962
Abstract: Severe resistance of doxorubicin (DOX) caused by drug efflux and immunosuppression has led to a high treatment failure risk of breast cancer (BC). Compared with the single atom nanozymes, the bi‐single‐atomic nanozymes obtained through sequential… read more here.
Keywords: dox; ros amplification; single atom; resistance ... See more keywords
Surface Nanotube Engineering of Iodine‐125 Seed for Combination of Chemotherapy and Brachytherapy
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DOI: 10.1002/adfm.202415436
Abstract: Iodine‐125 (125I) brachytherapy, in combination with chemotherapy, is extensively utilized for tumor treatment. However, the primary challenge in concurrently implementing brachy‐chemotherapy involves integrating the in situ implantation of 125I seeds with the systematic administration of… read more here.
Keywords: seed; 125i tnt; dox; iodine 125 ... See more keywords
Targeted Heating of Mitochondria Greatly Augments Nanoparticle-Mediated Cancer Chemotherapy.
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DOI: 10.1002/adhm.202000181
Abstract: Cancer is the second leading cause of mortality globally. Various nanoparticles have been developed to improve the efficacy and safety of chemotherapy, photothermal therapy, and their combination for treating cancer. However, most of the existing… read more here.
Keywords: chemotherapy; heating mitochondria; nanoparticle; dox ... See more keywords
Porous silicon nanocarriers with stimulus-cleavable linkers for effective cancer therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202200076
Abstract: Porous silicon nanoparticles (pSiNPs) have been widely utilized as drug carriers due to their excellent biocompatibility, large surface area and versatile surface chemistry. However, the dispersion in pore size and biodegradability of pSiNPs arguably have… read more here.
Keywords: cleavable linkers; drug; stimulus cleavable; dox ... See more keywords
Boosting Doxorubicin‐Induced Mitochondria Apoptosis for the Monodrug‐Mediated Combination of Chemotherapy and Chemodynamic Therapy
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DOI: 10.1002/adhm.202202045
Abstract: Doxorubicin (Dox)‐mediated generation of reactive oxygen radicals (ROS) for mitochondrial apoptosis is identified as a new cytotoxic mechanism in addition to the well‐established one via nuclear DNA replication interference. However, this mechanism contributes far less… read more here.
Keywords: apoptosis; dox; combination; doxorubicin ... See more keywords
A Novel Tri‐Functional Liposome Re‐Educates “Cold Tumor” and Abrogates Tumor Growth by Synergizing Autophagy Inhibition and PD‐L1 Blockade
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202757
Abstract: Immunotherapy has been regarded as a breakthrough in cancer treatment and achieved great success. However, the poor response rate is still a formidable challenge of current immunotherapies, especially in solid tumors without sufficient infiltration of… read more here.
Keywords: tumor growth; cold tumor; dox; novel tri ... See more keywords
DNA Framework‐Enabled 3D Organization of Antiarrhythmic Drugs for Radiofrequency Catheter Ablation
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DOI: 10.1002/adma.202401960
Abstract: Preorganizing molecular drugs within a microenvironment is crucial for the development of efficient and controllable therapeutic systems. Here, the use of tetrahedral DNA framework (TDF) is reported to preorganize antiarrhythmic drugs (herein doxorubicin, Dox) in… read more here.
Keywords: ablation; dox; dna framework; catheter ablation ... See more keywords
Self‐Stabilized Hyaluronate Nanogel for Intracellular Codelivery of Doxorubicin and Cisplatin to Osteosarcoma
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DOI: 10.1002/advs.201700821
Abstract: Abstract Osteosarcoma is one of the most serious bone malignancies with rapid speed of deterioration and low survival rate in children and teenagers. Chemotherapy is an important treatment for osteosarcoma, while the conventional small‐molecule therapeutics… read more here.
Keywords: cisplatin; osteosarcoma; self stabilized; cddp ... See more keywords
MT1‐MMP‐Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy
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DOI: 10.1002/advs.201902746
Abstract: Abstract Promoting tumor angiogenesis effectively and specifically to resolve tumor‐associated hypoperfusion holds promise for improving pancreatic cancer therapy. Herein, a doxorubicin (DOX) loaded smart liposome, MC‐T‐DOX, is constructed, that carries appropriately low‐density cilengitide, an αvβ3… read more here.
Keywords: mt1 mmp; pancreatic cancer; dox; therapy ... See more keywords