A Three-drug co-Delivery System Based on Reduction-sensitive Pol-ymeric Prodrug to Effectively Reverse Multi-drug Resistance
Sign Up to like & getrecommendations! Published in 2017 at "Chemical Research in Chinese Universities"
DOI: 10.1007/s40242-017-6450-1
Abstract: In the present study, we prepared a multi-drug delivery system based on reduction-sensitive paclitaxel (PTX) polymeric prodrug(PEG-b-PMPMC-g-PTX, PMP) polymersomes to co-deliver PTX, doxorubicin hydrochloride(DOX·HCl) and the P-glycoprotein(P-gp) inhibitor Tariquidar(TQR) to effectively reverse drug resistance by… read more here.
Keywords: drug; dox hcl; multi drug; reduction sensitive ... See more keywords
pH and redox dual-sensitive polysaccharide nanoparticles for the efficient delivery of doxorubicin.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials science"
DOI: 10.1039/c7bm00632b
Abstract: A pH and redox dual-sensitive biodegradable polysaccharide, succinic acid-decorated dextran-g-phenylalanine ethyl ester-g-cysteine ethyl ester (Dex-SA-l-Phe-l-Cys), was synthesized to load doxorubicin hydrochloride (DOX·HCl). The DOX-loaded nanoparticles, which were prepared in aqueous solution and free of organic… read more here.
Keywords: redox dual; dox nps; dox hcl; dox ... See more keywords
A Multimodal Theranostic System Prepared from High-Density Lipoprotein Carrier of Doxorubicin and 177Lu.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2021.3179
Abstract: Recently, it was demonstrated that doxorubicin (Dox.HCl), a chemotherapeutic agent, could be photoactivated by Cerenkov radiation (CR). The objective of the present work was to develop a multimodal chemotherapy-radiotherapy-photodynamic therapeutic system based on reconstituted high-density… read more here.
Keywords: high density; dox hcl; system; doxorubicin ... See more keywords
Drug-induced self-assembled nanovesicles for doxorubicin resistance reversal via autophagy inhibition and delivery synchronism
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.70852
Abstract: Background: As a classical autophagy inhibitor, CQ has been supposed to increase the sensitivity of tumors to chemotherapeutics. However, there exists a quite huge gap between laboratory research and clinical application, which is related to… read more here.
Keywords: drug induced; dox hcl; drug; delivery ... See more keywords