Antitumor efficacy and cardiotoxic effect of doxorubicin-loaded mixed micelles in 4T1 murine breast cancer model. Comparative studies using Doxil® and free doxorubicin
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2020.101506
Abstract: Abstract Doxorubicin-loaded mixed micelles (DOX-micelles) were formulated employing TPGS and a poloxamine (Tetronic® T1107) in order to investigate their pharmaceutical application as an alternative anticancer nanotherapy. DOX-micelles presented unimodal behaviour, exhibiting average size values of… read more here.
Keywords: dox micelles; doxorubicin; loaded mixed; effect ... See more keywords
Thermo and pH dual-responsive drug-linked pseudo-polypeptide micelles with a comb-shaped polymer as a micellar exterior
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DOI: 10.1039/c7py01389b
Abstract: Herein, thermo and pH dual-responsive drug-linked pseudo-polypeptide micelles were prepared by a self-assembly strategy. Initially, a temperature-responsive comb-shaped poly(2-isopropyl-2-oxazoline)-b-linear poly(acrylic acid) block copolymer (CPiPrOx-b-PAA) was synthesized through a combination of living cationic ring-opening polymerization and… read more here.
Keywords: paa dox; comb shaped; dox micelles; cpiprox paa ... See more keywords
Preparation of Micelles Encapsulating Doxorubicin and Their Anticancer Effect in Combination With Tranilast in 3D Spheroids and In Vivo
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DOI: 10.21873/anticanres.15766
Abstract: Background/Aim: The objective of this study was to prepare doxorubicin encapsulated in micelles (DOX-micelles) using poly(hexadecanyloxyethylene glycol-lactate phosphate), which we recently synthesized, and to evaluate the anticancer effect of DOX-micelles in vitro and in vivo.… read more here.
Keywords: anticancer effect; combination; effect; dox micelles ... See more keywords
Intelligent Drug Delivery by Peptide-Based Dual-Function Micelles
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23179698
Abstract: To endow the polymeric prodrug with smart properties through a safe and simple method, matrix metalloproteinase (MMPs) responsive peptide GPLGVRGDG was introduced into the block copolymer to prepare TPGS3350-GPLGVRGDG-DOX&DOX micelles, where TPGS3350 is D-α-tocopheryl polyethylene… read more here.
Keywords: dox micelles; dox; tpgs3350 gplgvrgdg; peptide ... See more keywords