Rational Design of Daunorubicin C-14 Hydroxylase Based on the Understanding of Its Substrate-Binding Mechanism
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24098337
Abstract: Doxorubicin is one of the most widely used antitumor drugs and is currently produced via the chemical conversion method, which suffers from high production costs, complex product separation processes, and serious environmental pollution. Biocatalysis is… read more here.
Keywords: daunorubicin; substrate binding; doxa; daunorubicin hydroxylase ... See more keywords
Functional expression and purification of DoxA, a key cytochrome P450 from Streptomyces peucetius ATCC 27952
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DOI: 10.7717/peerj.14373
Abstract: The antitumor drug doxorubicin is widely used in clinical practice. However, the low yield and high cost of this drug highlight the urgent need for cost-effective processes to rapidly manufacture antitumor drugs at scale. In… read more here.
Keywords: functional expression; cytochrome p450; doxa;