Inhibitory Effect of Tricyclic Antidepressant Doxepin on Voltage-Dependent K+ Channels in Rabbit Coronary Arterial Smooth Muscle Cells
Sign Up to like & getrecommendations! Published in 2019 at "Cardiovascular Toxicology"
DOI: 10.1007/s12012-019-09519-8
Abstract: Doxepin, tricyclic antidepressant, is widely used for the treatment of depressive disorders. Our present study determined the inhibitory effect of doxepin on voltage-dependent K+ (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells… read more here.
Keywords: doxepin; tricyclic antidepressant; voltage dependent; inhibitory effect ... See more keywords
Highly sensitive LC–MS/MS method to estimate doxepin and its metabolite nordoxepin in human plasma for a bioequivalence study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical Analysis"
DOI: 10.1016/j.jpha.2017.06.004
Abstract: A selective, sensitive and rugged liquid chromatography–tandem mass spectrometry (LC–MS/MS) assay has been developed for the simultaneous determination of doxepin (Dox) and its pharmacologically active metabolite, nordoxepin (NDox) in human plasma. The analytes and their… read more here.
Keywords: plasma; doxepin; metabolite nordoxepin; human plasma ... See more keywords