Boosting Doxorubicin‐Induced Mitochondria Apoptosis for the Monodrug‐Mediated Combination of Chemotherapy and Chemodynamic Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202045
Abstract: Doxorubicin (Dox)‐mediated generation of reactive oxygen radicals (ROS) for mitochondrial apoptosis is identified as a new cytotoxic mechanism in addition to the well‐established one via nuclear DNA replication interference. However, this mechanism contributes far less… read more here.
Keywords: apoptosis; dox; combination; doxorubicin ... See more keywords
Self‐Stabilized Hyaluronate Nanogel for Intracellular Codelivery of Doxorubicin and Cisplatin to Osteosarcoma
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DOI: 10.1002/advs.201700821
Abstract: Abstract Osteosarcoma is one of the most serious bone malignancies with rapid speed of deterioration and low survival rate in children and teenagers. Chemotherapy is an important treatment for osteosarcoma, while the conventional small‐molecule therapeutics… read more here.
Keywords: cisplatin; osteosarcoma; self stabilized; cddp ... See more keywords
Effect of tannic acid on doxorubicin‐induced cellular stress: Expression levels of heat shock genes in rat spleen
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.2633
Abstract: Doxorubicin (DOX), an anthracycline group antibiotic, has been extensively employed as a potent chemotherapeutic agent for treating solid and hematopoietic tumors in humans. Amid exposure to diverse stress conditions, living organisms swiftly initiate the synthesis… read more here.
Keywords: expression levels; heat shock; tannic acid; rat spleen ... See more keywords
Resveratrol promotes sensitization to Doxorubicin by inhibiting epithelial‐mesenchymal transition and modulating SIRT1/β‐catenin signaling pathway in breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.1993
Abstract: Breast cancer is one of the leading fatal diseases for women worldwide who cannot have surgery typically have to rely on systemic chemotherapy to extend their survival. Doxorubicin (DOX) is one of the most commonly… read more here.
Keywords: sirt1 catenin; breast cancer; epithelial mesenchymal; doxorubicin ... See more keywords
Simultaneous proteasome and autophagy inhibition synergistically enhances cytotoxicity of doxorubicin in breast cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3704
Abstract: Ubiquitin–proteasome system (UPS) and autophagy are interconnected proteolysis pathways implicated in doxorubicin resistance of breast cancer cells. Following anticancer treatments, autophagy either plays a cytoprotective role or augments treatment‐induced cytotoxicity. However, the role of autophagy… read more here.
Keywords: doxorubicin ixazomib; breast cancer; cancer cells; doxorubicin ... See more keywords
Protection of Adipose Tissue by Pioglitazone in a Mouse Model of Doxorubicin Treatment
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.70120
Abstract: Cancer is a global epidemic with increasing incidence, which needs continuous efforts to enhance treatment efficacy and reduce side effects. Our study focuses on the impact of doxorubicin, a widely used chemotherapeutic agent, on white… read more here.
Keywords: adipose tissue; doxorubicin; pioglitazone; doxorubicin treatment ... See more keywords
The Influence of Cyanine 5.5 and Doxorubicin on Cell Cycle Arrest, Magnetic Resonance, and Near‐Infrared Fluorescence Optical Imaging for Fe3O4‐Encapsulated PLA‐TPGS Nanoparticles
Sign Up to like & getrecommendations! Published in 2024 at "ChemMedChem"
DOI: 10.1002/cmdc.202400586
Abstract: The combination of magnetic resonance imaging (MRI)/near‐infrared (NIR) fluorescence signals and chemotherapy agents has been developed for cancer diagnosis and treatment. In this work, we investigated the impacts of Cyanine 5.5 and Doxorubicin on cell… read more here.
Keywords: fe3o4; cyanine doxorubicin; cell cycle; cycle arrest ... See more keywords
Ferroptosis: Latest evidence and perspectives on plant‐derived natural active compounds mitigating doxorubicin‐induced cardiotoxicity
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4670
Abstract: Doxorubicin (DOX) is a chemotherapy drug widely used in clinical settings, acting as a first‐line treatment for various malignant tumors. However, its use is greatly limited by the cardiotoxicity it induces, including doxorubicin‐induced cardiomyopathy (DIC).… read more here.
Keywords: ferroptosis latest; plant; cardiotoxicity; ferroptosis ... See more keywords
Enhanced anticancer potency of doxorubicin in combination with curcumin in gastric adenocarcinoma
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DOI: 10.1002/jbt.22486
Abstract: Gastric cancer (GC) is one of the prevalent human malignancies and the third most common cause of cancer‐related death worldwide. The doxorubicin hydrochloride is one of the important chemotherapeutic anticancer agents, with a limited therapeutic… read more here.
Keywords: curcumin doxorubicin; combination; gastric adenocarcinoma; dox cur ... See more keywords
Antioxidant, antiapoptotic, and antifibrotic effects of the combination of liposomal resveratrol and carvedilol against doxorubicin‐induced cardiomyopathy in rats
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22492
Abstract: The use of the cytotoxic antibiotic doxorubicin (DOXR) is limited by its dose‐dependent cardiotoxicity. The aim of this study was to evaluate the cardioprotective effect of the combination of carvedilol (CARD) and liposomal resveratrol (LIPO… read more here.
Keywords: combination; cardiomyopathy rats; liposomal resveratrol; doxorubicin ... See more keywords
Synergistic effect of anethole and doxorubicin alleviates cell proliferation, cell cycle arrest, and ER stress and promotes ROS-mediated apoptosis in triple-negative breast cancer cells.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.22928
Abstract: The heterogeneity and poor prognosis of triple-negative breast cancer (TNBC) have limited the treatment options and made clinical management challenging. This has nurtured a major effort to discover druggable molecular targets. Currently, chemotherapy is the… read more here.
Keywords: cell cycle; effect; anethole doxorubicin; doxorubicin ... See more keywords