Methylglyoxal at metronomic doses sensitizes breast cancer cells to doxorubicin and cisplatin causing synergistic induction of programmed cell death and inhibition of stemness
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.08.041
Abstract: Graphical abstract Figure. No Caption available. Abstract Potent anticancer activity coupled with absence of toxicity at therapeutic dose established the glycolytic metabolite, methylglyoxal, as a promising candidate against malignant neoplasia. In this preclinical study we… read more here.
Keywords: cancer; methylglyoxal; doxorubicin cisplatin; breast cancer ... See more keywords
In vitro and in vivo activity of thermosensitive liposomes loaded with doxorubicin and cisplatin
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DOI: 10.1080/03639045.2022.2102648
Abstract: Abstract Thermosensitive liposomes loaded with cisplatin and doxorubicin composed of DPPC, DSPC, and DPPE-PEG5000 with different ratios were prepared by thin film hydration method. The Differential Scanning Calorimetry (DSC) curves showed that the liposomes composed… read more here.
Keywords: doxorubicin cisplatin; results showed; doxorubicin; thermosensitive liposomes ... See more keywords
Methotrexate-Etoposide-Ifosfamide Compared with Doxorubicin-Cisplatin-Ifosfamide Chemotherapy in Osteosarcoma Treatment, Patients Aged 18-25 Years.
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DOI: 10.1089/jayao.2019.0085
Abstract: Purpose: The French standard chemotherapy for osteosarcoma combines high-dose methotrexate (HDM) and etoposide-ifosfamide (EI) in children and adolescents, and API-AI (doxorubicin-cisplatin-ifosfamide) in adults. We herein present the results of M-EI and API-AI in 18- to… read more here.
Keywords: chemotherapy; etoposide ifosfamide; chemotherapy osteosarcoma; doxorubicin cisplatin ... See more keywords
In situ Co-Delivery of Doxorubicin and Cisplatin by Injectable Thermosensitive Hydrogels for Enhanced Osteosarcoma Treatment
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DOI: 10.2147/ijn.s356453
Abstract: Purpose Osteosarcoma is considered as the most common primary malignant bone tumor in children and adolescents, and the treatments including chemotherapy and surgery were far from satisfactory. Localized tumor treatments by hydrogels incorporating combined chemotherapeutic… read more here.
Keywords: anti tumor; hydrogel; doxorubicin cisplatin; treatment ... See more keywords
Sulforaphane Potentiates Anticancer Effects of Doxorubicin and Cisplatin and Mitigates Their Toxic Effects
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DOI: 10.3389/fphar.2020.00567
Abstract: The success of cancer therapy is often compromised by the narrow therapeutic index of many anticancer drugs and the occurrence of drug resistance. The association of anticancer therapies with natural compounds is an emerging strategy… read more here.
Keywords: sulforaphane potentiates; cisplatin mitigates; doxorubicin cisplatin; potentiates anticancer ... See more keywords