Recombinant methioninase in combination with doxorubicin (DOX) overcomes first-line DOX resistance in a patient-derived orthotopic xenograft nude-mouse model of undifferentiated spindle-cell sarcoma.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.12.028
Abstract: We have previously established a patient-derived orthotopic xenograft (PDOX) model of undifferentiated spindle cell sarcoma (USCS). Recombinant methioninase (rMETase) has previously demonstrated efficacy in PDOX mouse models of human cancers. In the present study, we… read more here.
Keywords: first line; dox resistance; resistance; dox ... See more keywords
Histone deacetylase 2 regulates the doxorubicin (Dox) resistance of hepatocarcinoma cells and transcription of ABCB1
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.11.043
Abstract: ABSTRACT Histone deacetylases (HDACs) can regulate cell‐cycle, differentiation, and apoptosis of hepatocarcinoma (HCC) cells, while their roles in drug sensitivity remain unclear. Our results showed that the expression of HDAC2 was significantly increased in HCC… read more here.
Keywords: hcc; transcription abcb1; cells transcription; dox ... See more keywords
Varied effects of doxorubicin (DOX) on the corpus luteum of C57BL/6 mice during early pregnancy.
Sign Up to like & getrecommendations! Published in 2021 at "Biology of reproduction"
DOI: 10.1093/biolre/ioab180
Abstract: Certain chemotherapeutic drugs are toxic to ovarian follicles. The corpus luteum (CL) is normally developed from an ovulated follicle for producing progesterone (P4) to support early pregnancy. To fill in the knowledge gap about effects… read more here.
Keywords: corpus luteum; doxorubicin dox; early pregnancy; c57bl mice ... See more keywords
Doxorubicin (DOX) Gadolinium–Gold-Complex: A New Way to Tune Hybrid Nanorods as Theranostic Agent
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s295809
Abstract: Introduction In this paper, we have designed and formulated, a novel synthesis of doxorubicin (DOX) loaded bimetallic gold nanorods in which gold salt (HAuCl4) is chelated with anthracycline (DOX), diacid polyethylene-glycol (PEG-COOH) and gadolinium salt… read more here.
Keywords: doxorubicin dox; dox; doxorubicin; dox gadolinium ... See more keywords