Involvement of Yes‐associated protein 1 (YAP1) in doxorubicin‐induced cytotoxicity in H9c2 cardiac cells
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology International"
DOI: 10.1002/cbin.11285
Abstract: Cardiac cell death is one of the major events implicated in doxorubicin‐induced cardiotoxicity, which leads to heart failure. We recently reported that Yes‐associated protein 1 (YAP1) regulates cell survival and apoptosis. However, it is unclear… read more here.
Keywords: protein; yap1; doxorubicin induced; cell death ... See more keywords
Naringin against doxorubicin‐induced hepatotoxicity in mice through reducing oxidative stress, inflammation, and apoptosis via the up‐regulation of SIRT1
Sign Up to like & getrecommendations! Published in 2023 at "Environmental Toxicology"
DOI: 10.1002/tox.23755
Abstract: Clinical application of doxorubicin is limited because of its potential side effects. The present study examined whether naringin had protective actions on doxorubicin‐induced liver injury. Male BALB/c mice and alpha mouse liver 12 (AML‐12) cells… read more here.
Keywords: apoptosis; oxidative stress; doxorubicin; naringin doxorubicin ... See more keywords
Cardiac safety profile of patients receiving high cumulative doses of pegylated-liposomal doxorubicin: use of left ventricular ejection fraction is of unproven value
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-017-3420-8
Abstract: PurposeOne of the great conundrums for both oncologists and cardiologists is how to best monitor the potential and actual cardiotoxicity of doxorubicin. Pegylated-liposomal doxorubicin (PLD) has a safer cardiotoxicity profile than bolus administration of doxorubicin.… read more here.
Keywords: doxorubicin induced; pegylated liposomal; pld; patients receiving ... See more keywords
Antioxidant and Protective Effects of Schinus terebinthifolius Raddi Against Doxorubicin-Induced Toxicity
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DOI: 10.1007/s12010-017-2589-y
Abstract: Doxorubicin is an anticancer drug whose toxic effects on non-cancer cells are associated with increased oxidative stress. This study investigated the chemical composition, antioxidant activity of the methanolic extract of Schinus terebinthifolius Raddi leaves (MESL)… read more here.
Keywords: schinus terebinthifolius; doxorubicin induced; induced toxicity; terebinthifolius raddi ... See more keywords
Doxorubicin-Induced Cardiotoxicity: An Overview on Pre-clinical Therapeutic Approaches.
Sign Up to like & getrecommendations! Published in 2022 at "Cardiovascular toxicology"
DOI: 10.1007/s12012-022-09721-1
Abstract: Doxorubicin is an effective chemotherapeutic agent prescribed to treat solid tumors (e.g., ovary, breast, and gastrointestinal cancers). This anti-cancer drug has various side effects, such as allergic reactions, cardiac damage, hair loss, bone marrow suppression,… read more here.
Keywords: induced cardiotoxicity; heart failure; congestive heart; doxorubicin ... See more keywords
Salidroside Attenuates Doxorubicin-Induced Cardiac Dysfunction Partially Through Activation of QKI/FoxO1 Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cardiovascular Translational Research"
DOI: 10.1007/s12265-020-10056-x
Abstract: Doxorubicin (DOX) is an effective chemotherapy. However, its usage has been associated with adverse effects. Salidroside (SAL) is an antioxidative drug, which confers protective effects against several diseases. Salidroside can attenuate cardiac dysfunction induced by… read more here.
Keywords: attenuates doxorubicin; doxorubicin induced; qki; dysfunction ... See more keywords
123I-MIBG for detection of subacute doxorubicin-induced cardiotoxicity in patients with malignant lymphoma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Nuclear Cardiology"
DOI: 10.1007/s12350-018-01566-y
Abstract: BackgroundDoxorubicin is the mainstay of curative lymphoma treatment but is associated with a dose-dependent cardiotoxicity that is often recognized too late to avoid substantial irreversible cardiac injury. Iodine-123 metaiodobenzylguanidine (123I-MIBG) is a gamma-emitting tracer that… read more here.
Keywords: 123i mibg; cardiotoxicity; doxorubicin induced; detection ... See more keywords
Formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori coccon shell extract, Flaxseed oil and coenzyme Q10 against doxorubicin induced cardiomyopathy in rats
Sign Up to like & getrecommendations! Published in 2019 at "Oriental Pharmacy and Experimental Medicine"
DOI: 10.1007/s13596-019-00360-6
Abstract: The present study aims at formulation development and pharmacological evaluation of fixed dose combination of Bombyx mori (Abresham) extract, Flaxseed oil and coenzyme Q10 (CoQ10) against doxorubicin induced myocardial toxicity in rats. Formulation (emulsion) was… read more here.
Keywords: doxorubicin induced; dose combination; flaxseed oil; fixed dose ... See more keywords
MiR-124 attenuates doxorubicin-induced cardiac injury via inhibiting p66Shc-mediated oxidative stress.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.10.157
Abstract: Previous studies showed that miR-124 had a protective role by reducing oxidant stress and preventing cell apoptosis and autophagy. However, its role in doxorubicin-induced cardiomyopathy was less known. In our study, we confirmed increased ROS… read more here.
Keywords: 124 attenuates; doxorubicin induced; stress; p66shc ... See more keywords
Oxidized phospholipids in Doxorubicin-induced cardiotoxicity.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.01.032
Abstract: Doxorubicin (Dox), a widely used chemotherapy drug, can also cause cardiotoxic effects leading to heart failure. The excessive oxidative stress caused by Dox results in the modification of a variety of cellular molecules, including phospholipids.… read more here.
Keywords: oxidized phospholipids; doxorubicin induced; induced cardiotoxicity; phospholipids doxorubicin ... See more keywords
β-caryophyllene, a dietary phytocannabinoid attenuates oxidative stress, inflammation, apoptosis and prevents structural alterations of the myocardium against doxorubicin-induced acute cardiotoxicity in rats: An in vitro and in vivo study.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172467
Abstract: The present study investigates the cardioprotective effect of β-caryophyllene against doxorubicin-induced acute cardiotoxicity in rats. Doxorubicin (12.5 mg/kg) and β-caryophyllene (25, 50 or 100 mg/kg) were administered intraperitoneally to male albino Wistar rats. Doxorubicin-injected rats showed elevated… read more here.
Keywords: doxorubicin induced; acute cardiotoxicity; cardiotoxicity rats; doxorubicin ... See more keywords